rdf:type |
|
lifeskim:mentions |
umls-concept:C0011847,
umls-concept:C0017337,
umls-concept:C0082226,
umls-concept:C0167627,
umls-concept:C0205419,
umls-concept:C0272051,
umls-concept:C0332281,
umls-concept:C0489835,
umls-concept:C1539081,
umls-concept:C1611184,
umls-concept:C1844680
|
pubmed:issue |
3
|
pubmed:dateCreated |
2006-2-28
|
pubmed:abstractText |
CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules. These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1097-6744
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
151
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
706-11
|
pubmed:dateRevised |
2010-12-3
|
pubmed:meshHeading |
pubmed-meshheading:16504636-Antigens, CD40,
pubmed-meshheading:16504636-C-Reactive Protein,
pubmed-meshheading:16504636-CD40 Ligand,
pubmed-meshheading:16504636-Calcium,
pubmed-meshheading:16504636-Coronary Artery Disease,
pubmed-meshheading:16504636-Coronary Vessels,
pubmed-meshheading:16504636-Diabetic Angiopathies,
pubmed-meshheading:16504636-Disease Progression,
pubmed-meshheading:16504636-Female,
pubmed-meshheading:16504636-Genetic Variation,
pubmed-meshheading:16504636-Genotype,
pubmed-meshheading:16504636-Humans,
pubmed-meshheading:16504636-Linkage Disequilibrium,
pubmed-meshheading:16504636-Male,
pubmed-meshheading:16504636-Middle Aged,
pubmed-meshheading:16504636-Polymorphism, Single Nucleotide
|
pubmed:year |
2006
|
pubmed:articleTitle |
Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS).
|
pubmed:affiliation |
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|