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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-3-30
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pubmed:abstractText |
EGF receptor acts through Ras and the MAPK cascade to trigger differentiation and maintain survival of most of cell types in the Drosophila retina. Cell types are specified sequentially by separate episodes of EGFR activity. All the cell types differentiate in G1 phase of the cell cycle. Before differentiating, many cells pass through the cell cycle in the "Second Mitotic Wave" in response to Notch activity, but no cell fates are specified during the Second Mitotic Wave. It is not known how fate specification is limited to G1-arrested cells.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-213X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16504047-Animals,
pubmed-meshheading:16504047-Cell Cycle,
pubmed-meshheading:16504047-Cell Differentiation,
pubmed-meshheading:16504047-Drosophila,
pubmed-meshheading:16504047-Drosophila Proteins,
pubmed-meshheading:16504047-Mitosis,
pubmed-meshheading:16504047-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:16504047-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:16504047-Receptors, Notch,
pubmed-meshheading:16504047-Retina
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pubmed:year |
2006
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pubmed:articleTitle |
Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye.
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pubmed:affiliation |
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. lihuiy@bcm.tmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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