Source:http://linkedlifedata.com/resource/pubmed/id/16479190
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-2-15
|
| pubmed:abstractText |
In the atherosclerotic plaque, cyclooxygenase-2 (COX-2) catalyzes prostaglandin E formation, which acts as a pro-atherogenic factor. A polymorphism, G/C -765, within the COX-2 promoter region modulates gene expression and the risk of cerebrovascular disease. We have evaluated the relation between COX-2 G/C -765 genotypes and the occurrence of cerebrovascular ischemia. We evaluated the COX-2 G/C -765 polymorphism in 110 consecutive patients with a documented history of acute ischemic cerebrovascular disease, in 110 age-matched and sex-matched subjects without such history, and in a general population (n = 324) from the same ethnical background. The frequency of the COX-2 -765C allele in patients [0.21; 95% confidence interval (CI), 0.16-0.26] was similar to those found in controls (0.28; 95% CI, 0.22-0.34) and in the general population (0.26; 95% CI, 0.23-0.29). Carriers of the CC genotype differed between patients (0.02; 95% CI, 0.00-0.05) and controls [0.10 (95% CI, 0.04-0.16), P = 0.019; odds ratio, 0.17 (95% CI, 0.04-0.79)] or the general population [0.08 (95% CI, 0.05-0.11), P = 0.023; odds ratio, 0.22 (95% CI, 0.05-0.95)]. In a multiple logistic regression analysis adjusted for confounding variables, smoking status (P < 0.001), atrial fibrillation (P = 0.004) and COX-2 G/C-765 polymorphism (P = 0.016) independently contributed to cerebrovascular ischemia, with CC carriers exhibiting a lower risk (odds ratio, 0.07; 95% CI, 0.01-0.61). Our data show an association between the COX-2 G/C-765 gene polymorphism and cerebrovascular ischemia, suggesting that the COX-2 gene is a susceptibility locus for the risk of cerebrovascular ischemic disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0957-5235
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-6
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:16479190-Adult,
pubmed-meshheading:16479190-Aged,
pubmed-meshheading:16479190-Aged, 80 and over,
pubmed-meshheading:16479190-Alleles,
pubmed-meshheading:16479190-Atherosclerosis,
pubmed-meshheading:16479190-Atrial Fibrillation,
pubmed-meshheading:16479190-Brain Ischemia,
pubmed-meshheading:16479190-Cyclooxygenase 2,
pubmed-meshheading:16479190-Female,
pubmed-meshheading:16479190-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:16479190-Gene Frequency,
pubmed-meshheading:16479190-Genetic Predisposition to Disease,
pubmed-meshheading:16479190-Humans,
pubmed-meshheading:16479190-Male,
pubmed-meshheading:16479190-Membrane Proteins,
pubmed-meshheading:16479190-Middle Aged,
pubmed-meshheading:16479190-Polymorphism, Single Nucleotide,
pubmed-meshheading:16479190-Predictive Value of Tests,
pubmed-meshheading:16479190-Promoter Regions, Genetic,
pubmed-meshheading:16479190-Quantitative Trait Loci,
pubmed-meshheading:16479190-Risk Factors
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia.
|
| pubmed:affiliation |
Unita' di Aterosclerosi e Trombosi, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
|