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pubmed-article:16457151pubmed:abstractTextThe HER2 gene encodes a 185-kd transmembrane glycoprotein receptor (p185(HER2)) that has partial homology with the epidermal growth factor receptor and shares intrinsic tyrosine kinase activity. The phosphatase and tensin homolog mutated on chromosome ten (PTEN) gene product is a protein tyrosine phosphatase that participates in modulating the phosphoinositide 3-kinase pathway which has antagonizing activity to protein tyrosine kinase. The authors investigated the correlation between clinicopathologic variables including survival and the overexpression of the p185(HER2) with loss of PTEN expression in gastric adenocarcinoma patients.lld:pubmed
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pubmed-article:16457151pubmed:articleTitlePotential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas.lld:pubmed
pubmed-article:16457151pubmed:affiliationSection of Oncology/Hematology, Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yongondong Chongnogu, Seoul, 110-744, Korea. moisa@snu.ac.krlld:pubmed
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