|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0035647,
umls-concept:C0069515,
umls-concept:C0185117,
umls-concept:C0220901,
umls-concept:C0237881,
umls-concept:C0242957,
umls-concept:C0694888,
umls-concept:C0699791,
umls-concept:C0750502,
umls-concept:C1514559,
umls-concept:C1517945,
umls-concept:C2911684
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-2-6
|
|
pubmed:abstractText |
The HER2 gene encodes a 185-kd transmembrane glycoprotein receptor (p185(HER2)) that has partial homology with the epidermal growth factor receptor and shares intrinsic tyrosine kinase activity. The phosphatase and tensin homolog mutated on chromosome ten (PTEN) gene product is a protein tyrosine phosphatase that participates in modulating the phosphoinositide 3-kinase pathway which has antagonizing activity to protein tyrosine kinase. The authors investigated the correlation between clinicopathologic variables including survival and the overexpression of the p185(HER2) with loss of PTEN expression in gastric adenocarcinoma patients.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0300-8916
|
|
pubmed:author |
pubmed-author:ChoMin-SunMS,
pubmed-author:HanHo-SeongHS,
pubmed-author:HanWoon SupWS,
pubmed-author:ImSeock-AhSA,
pubmed-author:KimDo YeunDY,
pubmed-author:LeeJoo-HoJH,
pubmed-author:LeeKyung EunKE,
pubmed-author:LeeSoon NamSN,
pubmed-author:NamEunmiE,
pubmed-author:ParkHae-YoungHY,
pubmed-author:SeohJu-YoungJY
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
91
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
513-21
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16457151-Adenocarcinoma,
pubmed-meshheading:16457151-Adult,
pubmed-meshheading:16457151-Aged,
pubmed-meshheading:16457151-Aged, 80 and over,
pubmed-meshheading:16457151-Down-Regulation,
pubmed-meshheading:16457151-Female,
pubmed-meshheading:16457151-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:16457151-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16457151-Humans,
pubmed-meshheading:16457151-Immunohistochemistry,
pubmed-meshheading:16457151-Male,
pubmed-meshheading:16457151-Middle Aged,
pubmed-meshheading:16457151-Neoplasm Staging,
pubmed-meshheading:16457151-PTEN Phosphohydrolase,
pubmed-meshheading:16457151-Predictive Value of Tests,
pubmed-meshheading:16457151-Prognosis,
pubmed-meshheading:16457151-Proportional Hazards Models,
pubmed-meshheading:16457151-Receptor, erbB-2,
pubmed-meshheading:16457151-Risk Factors,
pubmed-meshheading:16457151-Stomach Neoplasms,
pubmed-meshheading:16457151-Survival Analysis,
pubmed-meshheading:16457151-Tumor Markers, Biological,
pubmed-meshheading:16457151-Up-Regulation
|
|
pubmed:articleTitle |
Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas.
|
|
pubmed:affiliation |
Section of Oncology/Hematology, Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yongondong Chongnogu, Seoul, 110-744, Korea. moisa@snu.ac.kr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
