| pubmed-article:16453627 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:16453627 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:16453627 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16453627 | pubmed:dateCreated | 2010-6-28 | lld:pubmed |
| pubmed-article:16453627 | pubmed:abstractText | Multigene and non-genic DNA families are in a state of turnover and hence are continually being replaced throughout a population by new variant repeats. To quantify such molecular processes, in the absence of selection, it is necessary to find and compare stages of transistion during the homogenization of at least two non-genic families evolving in parallel in a closely related group of species. Detailed sequence analysis of patterns of variation, at each nucleotide position considered independently, amongst repeats of two tandem DNA families from seven related Drosophila species, reveals all stages of transition during the spread of randomly produced variant repeats. Variant repeats are found at different stages of homogenization and fixation in a population, irrespective of the loci, chromosomes or individuals from which they were cloned. Differences between the families in the relatively small number of variants at each transition stage and the greater number of fully homogenized and fixed variants between species of greater divergence indicate that the process of spread (molecular drive) is rapid relative to the mutation rate and occurs at seemingly different constant rates for each family. Occasional gene conversions, in addition to unequal exchanges, have contributed to family turnover. The significance of these results to the evolution of functional multigene families and divergence and conservation of sequences is discussed. | lld:pubmed |
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| pubmed-article:16453627 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16453627 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16453627 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:16453627 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16453627 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:16453627 | pubmed:author | pubmed-author:DoverG AGA | lld:pubmed |
| pubmed-article:16453627 | pubmed:author | pubmed-author:VEISR ARA | lld:pubmed |
| pubmed-article:16453627 | pubmed:author | pubmed-author:StrachanTT | lld:pubmed |
| pubmed-article:16453627 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16453627 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:16453627 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16453627 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16453627 | pubmed:pagination | 1701-8 | lld:pubmed |
| pubmed-article:16453627 | pubmed:dateRevised | 2010-9-20 | lld:pubmed |
| pubmed-article:16453627 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:16453627 | pubmed:articleTitle | Transition stages of molecular drive in multiple-copy DNA families in Drosophila. | lld:pubmed |
| pubmed-article:16453627 | pubmed:affiliation | Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. | lld:pubmed |
| pubmed-article:16453627 | pubmed:publicationType | Journal Article | lld:pubmed |
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