Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-6-28
pubmed:abstractText
Multigene and non-genic DNA families are in a state of turnover and hence are continually being replaced throughout a population by new variant repeats. To quantify such molecular processes, in the absence of selection, it is necessary to find and compare stages of transistion during the homogenization of at least two non-genic families evolving in parallel in a closely related group of species. Detailed sequence analysis of patterns of variation, at each nucleotide position considered independently, amongst repeats of two tandem DNA families from seven related Drosophila species, reveals all stages of transition during the spread of randomly produced variant repeats. Variant repeats are found at different stages of homogenization and fixation in a population, irrespective of the loci, chromosomes or individuals from which they were cloned. Differences between the families in the relatively small number of variants at each transition stage and the greater number of fully homogenized and fixed variants between species of greater divergence indicate that the process of spread (molecular drive) is rapid relative to the mutation rate and occurs at seemingly different constant rates for each family. Occasional gene conversions, in addition to unequal exchanges, have contributed to family turnover. The significance of these results to the evolution of functional multigene families and divergence and conservation of sequences is discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-106393, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-112914, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-231676, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-378397, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-4208791, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-461194, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6154869, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6260016, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6276556, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6294625, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6409420, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6439886, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6488313, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6500260, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6575397, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6609814, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6749748, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6799840, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6801626, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6802066, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6811755, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6811756, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-6996571, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-7040165, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-7049398, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-7110332, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-7161811, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-7265203, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-813561, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-845942, http://linkedlifedata.com/resource/pubmed/commentcorrection/16453627-99293
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jul
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1701-8
pubmed:dateRevised
2010-9-20
pubmed:year
1985
pubmed:articleTitle
Transition stages of molecular drive in multiple-copy DNA families in Drosophila.
pubmed:affiliation
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
pubmed:publicationType
Journal Article