Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-26
pubmed:abstractText
In UM-X7.1 hamster model of human dilated cardiomyopathy, heart failure progressively develops and causes 50% mortality by 30 weeks of age. Through ultrastructural analysis, we found that many cardiomyocytes of this model contain typical autophagic vacuoles including degraded mitochondria, glycogen granules, and myelin-like figures. In addition, ubiquitin, cathepsin D, and Rab7 were overexpressed as determined by immunoassays. Importantly, most cardiomyocytes with leaky plasma membranes were positive for cathepsin D, suggesting a direct link between autophagic degeneration and cell death. Meanwhile, cardiomyocyte apoptosis appeared insignificant. Granulocyte colony-stimulating factor (10 microg/kg/day), injected 5 days/week from 15 to 30 weeks of age, improved survival among 30-week-old hamsters (100% versus 53% in the untreated hamsters, P < 0.0001); ventricular function and remodeling, increased cardiomyocyte size, and reduced myocardial fibrosis followed by a dramatic reduction in the autophagic findings were also seen. Granulocyte colony-stimulating factor also down-regulated tumor necrosis factor-alpha and increased activities of Akt signal transducer and activator of transcription-3, and matrix metalloproteinases. However, there was no clear evidence of transdifferentiation from bone marrow cells into cardiomyocytes. In conclusion, autophagic death is important for cardiomyocyte loss in the cardiomyopathic hamster, and the beneficial effect of granulocyte colony-stimulating factor acts mainly via an anti-autophagic mechanism rather than anti-apo-ptosis or regeneration.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10351969, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10481911, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10502816, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10618415, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10688821, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10775477, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10880048, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10889138, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10972293, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10972294, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-10974018, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11099404, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11122135, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11160141, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11283669, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11305971, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11342461, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11470470, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11485926, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11504914, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11711481, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11716248, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11805334, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11818361, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-11909815, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12004790, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12025458, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12084167, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12456484, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12480812, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12600911, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-12649263, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-13129932, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-13961526, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-14507992, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-14699058, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-14991064, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-15001565, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-15123535, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-15138286, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-15723072, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-2424918, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-6450334, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-7057801, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-7175947, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-830435, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-8509564, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-8704229, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-8815940, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-9099657, http://linkedlifedata.com/resource/pubmed/commentcorrection/16436654-9683425
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
386-97
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
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