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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1992-9-4
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pubmed:abstractText |
The cytosolic phospholipase A2 (PLA2) was characterized in the human epithelial carcinoma cell line HEp-2 by its apparent molecular mass (about 80 kDa); its in vitro activation by micromolar concentrations of calcium; and its calcium-dependent association with cellular membranes. The activity of this enzyme was induced by an overnight incubation with tumor necrosis factor alpha (TNF alpha). Glucocorticoids only moderately reduced PLA2 activity in control cells, but completely inhibited the TNF alpha-induced increase in the activity of the high-molecular-weight cytosolic PLA2.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-3002
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
29
|
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pubmed:volume |
1127
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
163-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1643102-Cytosol,
pubmed-meshheading:1643102-Dexamethasone,
pubmed-meshheading:1643102-Enzyme Induction,
pubmed-meshheading:1643102-Glucocorticoids,
pubmed-meshheading:1643102-Humans,
pubmed-meshheading:1643102-Molecular Weight,
pubmed-meshheading:1643102-Phospholipases A,
pubmed-meshheading:1643102-Phospholipases A2,
pubmed-meshheading:1643102-Tumor Cells, Cultured,
pubmed-meshheading:1643102-Tumor Necrosis Factor-alpha
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pubmed:year |
1992
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|
pubmed:articleTitle |
Glucocorticoids inhibit TNF alpha-induced cytosolic phospholipase A2 activity.
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pubmed:affiliation |
Institute of Molecular Pharmacology, Medical School Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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