Linked Life Data

16413100

Source:http://linkedlifedata.com/resource/pubmed/id/16413100

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-10-9
pubmed:abstractText
A dysregulated mitogen-activated protein kinase (MAPK) pathway plays an important role in various malignancies and is often mediated by mutations in several oncogenes (eg, RAF, RAS). B-RAF mutations, predominantly the specific V600E mutation and additional alterations in exons 11 and 15, were frequently detected in malignant melanomas, papillary thyroid tumors, and colorectal cancers with microsatellite instability (MSI). The present study investigated B-RAF mutations, MSI status, and activation of MAPK signaling in prostate tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0302-2838
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1102-9; discussion 1109-10
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16413100-Aged, pubmed-meshheading:16413100-Alleles, pubmed-meshheading:16413100-DNA, Neoplasm, pubmed-meshheading:16413100-DNA Mutational Analysis, pubmed-meshheading:16413100-Enzyme Activation, pubmed-meshheading:16413100-Exons, pubmed-meshheading:16413100-Female, pubmed-meshheading:16413100-Genome, Human, pubmed-meshheading:16413100-Glutamine, pubmed-meshheading:16413100-Humans, pubmed-meshheading:16413100-Immunohistochemistry, pubmed-meshheading:16413100-Male, pubmed-meshheading:16413100-Microsatellite Instability, pubmed-meshheading:16413100-Middle Aged, pubmed-meshheading:16413100-Mitogen-Activated Protein Kinases, pubmed-meshheading:16413100-Mutation, pubmed-meshheading:16413100-Polymerase Chain Reaction, pubmed-meshheading:16413100-Prostatic Neoplasms, pubmed-meshheading:16413100-Proto-Oncogene Proteins B-raf, pubmed-meshheading:16413100-Signal Transduction, pubmed-meshheading:16413100-Valine
pubmed:year
2006
pubmed:articleTitle
Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.
pubmed:affiliation
Department of Urology, University of Regensburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't