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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-3-11
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pubmed:abstractText |
Numerous studies have implicated spinal extracellular signal-regulated kinases (ERKs) as mediators of nociceptive plasticity. These studies have utilized pharmacological inhibition of MEK to demonstrate a role for ERK signaling in pain, but this approach cannot distinguish between effects of ERK in neuronal and non-neuronal cells. The present studies were undertaken to test the specific role of neuronal ERK in formalin-induced inflammatory pain. Dominant negative MEK (DN MEK) mutant mice in which MEK function is suppressed exclusively in neurons were tested in the formalin model of inflammatory pain.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16412244-10366647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16412244-10493730,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16412244-9786874
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2
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pubmed:dateRevised |
2010-3-23
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pubmed:meshHeading |
pubmed-meshheading:16412244-Animals,
pubmed-meshheading:16412244-Behavior, Animal,
pubmed-meshheading:16412244-Butadienes,
pubmed-meshheading:16412244-Enzyme Activation,
pubmed-meshheading:16412244-Formaldehyde,
pubmed-meshheading:16412244-Genes, Dominant,
pubmed-meshheading:16412244-Hot Temperature,
pubmed-meshheading:16412244-Hyperalgesia,
pubmed-meshheading:16412244-Inflammation,
pubmed-meshheading:16412244-Mice,
pubmed-meshheading:16412244-Mice, Transgenic,
pubmed-meshheading:16412244-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:16412244-Neurons,
pubmed-meshheading:16412244-Nitriles,
pubmed-meshheading:16412244-Pain,
pubmed-meshheading:16412244-Potassium Channels
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pubmed:year |
2006
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pubmed:articleTitle |
Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).
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