Linked Life Data

16398610

Source:http://linkedlifedata.com/resource/pubmed/id/16398610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-1-9
pubmed:abstractText
Cancer cells continue to grow, lose their differentiation, and are found beyond their tissue boundaries, where they survive. These phenomena lead to cancer invasion and metastasis and are responsible for the outcome of the disease in cancer patients. Different factors determine where and when the cells will metastasize. The surrounding host cells, such as fibroblasts, macrophages, leukocytes, et cetera, and the extracellular matrix play an important role in the creation of the microenvironment for the cancer cells to invade. Blood and lymph vessels are not only the transporters of nutrients and metabolites for the primary tumor, these vessels also transport cancer cells to distant sites, where they metastasize. Angiogenesis and host cells are targets in cancer treatment. To monitor therapy or to predict cancer relapses, circulating tumor markers are used that reflect the molecular cross-talk between cancer and stromal cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1084-9785
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
579-88
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Molecular targets of growth, differentiation, tissue integrity, and ectopic cell death in cancer cells.
pubmed:affiliation
Laboratory of Experimental Cancerology, Department of Radiotherapy, Nuclear Medicine, and Experimental Cancerology, Ghent University Hospital, Ghent, Belgium.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't