|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017287,
umls-concept:C0021149,
umls-concept:C0023449,
umls-concept:C0029016,
umls-concept:C0079611,
umls-concept:C0185117,
umls-concept:C0231335,
umls-concept:C0332466,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0524889,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2911684
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2006-6-8
|
|
pubmed:abstractText |
Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement is conventionally used for assessment of lymphoid malignant cells. TCR genes rearrangements were reported to occur at high frequency in B-lineage acute lymphoblastic leukemia (ALL). Therefore, we have analyzed 83 children with acute B-lineage ALL (67 de novo patients and 19 relapses) by PCR analysis for clonal IgH, incomplete TCRD (Vdelta2-Ddelta3 and Ddelta2-Ddelta3) and TCRG rearrangements. It was shown that clonal cross-lineage TCR rearrangements were associated with more immature immunophenotype (CD34+, CD117+, CyIgM-) of leukemic cells from patients' bone marrow (BM) samples as compared to cell samples without cross-lineage TCR rearrangements. That was equally detected both in de novo and relapsed cases of disease. Low frequency of clonal TCRG rearrangements was associated with expression of E2A/PBX chimeric oncogene. We suggest that TCRG and TCRD clonal rearrangements in leukemic B-cells are associated with early stages of their differentiation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/E2A-Pbx1 fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLL-AF4 fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-AML1 fusion protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0145-2126
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
30
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
795-800
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16386788-Adolescent,
pubmed-meshheading:16386788-Adult,
pubmed-meshheading:16386788-Burkitt Lymphoma,
pubmed-meshheading:16386788-Child,
pubmed-meshheading:16386788-Child, Preschool,
pubmed-meshheading:16386788-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:16386788-Female,
pubmed-meshheading:16386788-Fusion Proteins, bcr-abl,
pubmed-meshheading:16386788-Gene Expression Profiling,
pubmed-meshheading:16386788-Homeodomain Proteins,
pubmed-meshheading:16386788-Humans,
pubmed-meshheading:16386788-Immunophenotyping,
pubmed-meshheading:16386788-Infant,
pubmed-meshheading:16386788-Male,
pubmed-meshheading:16386788-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:16386788-Oncogene Proteins, Fusion,
pubmed-meshheading:16386788-Polymerase Chain Reaction,
pubmed-meshheading:16386788-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:16386788-Receptors, Antigen, T-Cell,
pubmed-meshheading:16386788-Recurrence,
pubmed-meshheading:16386788-Sensitivity and Specificity
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression.
|
|
pubmed:affiliation |
Belarusian Research Center for Pediatric Oncology & Hematology, Scientific Department, P.O. Lesnoye, 223052 Minsk, Belarus. meleshko@tut.by
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
