Source:http://linkedlifedata.com/resource/pubmed/id/16380494
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2005-12-28
|
pubmed:abstractText |
Individuals with chronically elevated glucose and/or insulin levels, i.e., most patients with type 2 diabetes, have accelerated atherosclerosis and are prone to acute vascular events. We have tested the hypothesis that hyperglycemia and/or hyperinsulinemia singly or combined may increase tissue factor, the primary initiator of blood coagulation. We have determined changes in circulating tissue factor procoagulant activity (PCA) and other procoagulation proteins in healthy volunteers exposed to 24 h of selective hyperinsulinemia, selective hyperglycemia, or combined hyperinsulinemia and hyperglycemia. Combined elevations of plasma insulin and glucose levels for 24 h produced a ninefold increase in tissue factor PCA, which was associated with an increase in monocyte tissue factor protein (flow cytometry) and mRNA (RT-PCR), increases in plasma thrombin-antithrombin complexes, prothrombin fragment 1.2, factor VIII coagulant activity, and platelet CD40 ligand as well as decreases in factor VIIa, factor VII coagulant activities, and factor VII antigen. Effects of selective hyperinsulinemia and selective hyperglycemia were less striking but appeared to be additive. We conclude that hyperinsulinemia and hyperglycemia but particularly the combination of both create a prothrombotic state and in addition may be proinflammatory and proatherogenic because of the proinflammatory actions of CD40 ligand and tissue factor.
|
pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/P30 DA 13429,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG 15353,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK 066003,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK 58895,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL 733267
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/F8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Factor VII,
http://linkedlifedata.com/resource/pubmed/chemical/Factor VIII,
http://linkedlifedata.com/resource/pubmed/chemical/Factor VIIa,
http://linkedlifedata.com/resource/pubmed/chemical/Prothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboplastin,
http://linkedlifedata.com/resource/pubmed/chemical/factor VII clotting antigen
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0012-1797
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
55
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
202-8
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:16380494-Adult,
pubmed-meshheading:16380494-Antigens,
pubmed-meshheading:16380494-Blood Platelets,
pubmed-meshheading:16380494-CD40 Ligand,
pubmed-meshheading:16380494-Factor VII,
pubmed-meshheading:16380494-Factor VIII,
pubmed-meshheading:16380494-Factor VIIa,
pubmed-meshheading:16380494-Female,
pubmed-meshheading:16380494-Gene Expression Regulation,
pubmed-meshheading:16380494-Glucose Clamp Technique,
pubmed-meshheading:16380494-Humans,
pubmed-meshheading:16380494-Hyperglycemia,
pubmed-meshheading:16380494-Hyperinsulinism,
pubmed-meshheading:16380494-Male,
pubmed-meshheading:16380494-Monocytes,
pubmed-meshheading:16380494-Prothrombin,
pubmed-meshheading:16380494-Thromboplastin
|
pubmed:year |
2006
|
pubmed:articleTitle |
Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand.
|
pubmed:affiliation |
Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|