Linked Life Data

16374593

Source:http://linkedlifedata.com/resource/pubmed/id/16374593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-1-4
pubmed:abstractText
The incidence of vancomycin-resistant Enterococcus faecium isolation was low (<or=5%) in German hospitals before 2003. Within the second half of 2003 and the first half of 2004, however, increasing frequencies of up to 14% were noticed in several hospitals in southwestern Germany. This increase was attributed mainly to the occurrence and spread of epidemic-virulent ampicillin/vancomycin-resistant, vanA- and vanB-positive E. faecium clones, most of which exhibited the virulence factors enterococcal surface protein (esp) and bacteriocin activity and some which exhibited hyaluronidase (hyl). E. faecium possessing hyaluronidase was initially found in U.S. hospitals and recently detected in several European hospitals and, subsequently, in German hospitals as well. Ampicillin/vancomycin-resistant E. faecium clones originating mainly from southwestern German hospitals were characterized by multilocus sequence typing since different sequence types (STs) belonging to the clonal complex-17 are currently disseminated worldwide. Multilocus sequence typing revealed that, in 1998 and 1999, ampicillin/vancomycin-resistant E. faecium clone ST-117 was prevalent in various German hospitals, while in 2003 and 2004, clone ST-203 dominated in several hospitals located in southwestern Germany. Both sequence types display single-locus variants of ST-78, which was frequently recorded in various Italian hospitals between 2000 and 2003, and all of these STs belong to the clonal complex-17. Expression of linezolid resistance was observed in ampicillin/glycopeptide-resistant E. faecium strains (VanA type) from two tertiary hospitals in southwestern Germany due to mutations in domain V of the 23S rDNA (G2576T). While in one hospital the resistance emerged during linezolid therapy, in the other hospital resistance was caused by transfer of an identical linezolid/ampicillin/glycopeptide-resistant E. faecium strain. In conclusion, it is very important to monitor the occurrence of epidemic-virulent clonal complex-17 strains of E. faecium to prevent their spread in hospitals, especially if they are resistant to glycopeptides and linezolid.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0934-9723
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
815-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16374593-Acetamides, pubmed-meshheading:16374593-Ampicillin Resistance, pubmed-meshheading:16374593-Anti-Infective Agents, pubmed-meshheading:16374593-Bacterial Proteins, pubmed-meshheading:16374593-Cross Infection, pubmed-meshheading:16374593-DNA Restriction Enzymes, pubmed-meshheading:16374593-Drug Resistance, Multiple, Bacterial, pubmed-meshheading:16374593-Enterococcus faecium, pubmed-meshheading:16374593-Germany, pubmed-meshheading:16374593-Gram-Positive Bacterial Infections, pubmed-meshheading:16374593-Humans, pubmed-meshheading:16374593-Hyaluronoglucosaminidase, pubmed-meshheading:16374593-Membrane Proteins, pubmed-meshheading:16374593-Oxazolidinones, pubmed-meshheading:16374593-Phenotype, pubmed-meshheading:16374593-Phylogeny, pubmed-meshheading:16374593-Polymerase Chain Reaction, pubmed-meshheading:16374593-Vancomycin Resistance
pubmed:year
2005
pubmed:articleTitle
Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals.
pubmed:affiliation
Robert Koch Institute, Wernigerode Branch, Burgstr. 37, 38855, Wernigerode, Germany. i.klare@rki.de
pubmed:publicationType
Journal Article, Review