Linked Life Data

16369894

Source:http://linkedlifedata.com/resource/pubmed/id/16369894

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-21
pubmed:abstractText
Orthodontic tooth movement is achieved by mechanical loading; however, the biological mechanism involved in this process is not clearly understood owing to the lack of a suitable experimental model. In the present study, we established an orthodontic tooth movement model in mice using a Ni-Ti closed coil spring that was inserted between the upper incisors and the upper first molar. Histological examination demonstrated that the orthodontic force moved the first upper molar mesially without necrosis of the periodontium during tooth movement. The number of TRAP-positive osteoclasts on the pressure side significantly increased in a time-dependent manner. Quantitative real time-based reverse transcription-polymerase chain reaction analysis demonstrated increased levels of mRNA for cathepsin K. Immunohistochemical staining revealed the expression of tumor necrosis factor-alpha (TNFalpha) in periodontium on the pressure side of the first molar during orthodontic tooth movement. When this tooth movement system was applied to TNF type 1 receptor-deficient mice and TNF type 2 receptor-deficient mice, tooth movement observed in TNF type 2 receptor-deficient mice was smaller than that in the wild-type mice and TNF type 1 receptor-deficient mice. The number of TRAP-positive osteoclasts on the pressure side was significantly small in TNF type 2 receptor-deficient mice compared with that in TNF type 1 receptor-deficient mice on day 6 after application of the appliance. The present study indicates that TNFalpha signaling plays some important roles in orthodontic tooth movement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0914-8779
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16369894-Acid Phosphatase, pubmed-meshheading:16369894-Animals, pubmed-meshheading:16369894-Biomechanics, pubmed-meshheading:16369894-Bone Remodeling, pubmed-meshheading:16369894-Cathepsin K, pubmed-meshheading:16369894-Cathepsins, pubmed-meshheading:16369894-Isoenzymes, pubmed-meshheading:16369894-Mice, pubmed-meshheading:16369894-Mice, Knockout, pubmed-meshheading:16369894-Models, Animal, pubmed-meshheading:16369894-Osteoclasts, pubmed-meshheading:16369894-Periodontium, pubmed-meshheading:16369894-RNA, Messenger, pubmed-meshheading:16369894-Receptors, Tumor Necrosis Factor, Type I, pubmed-meshheading:16369894-Receptors, Tumor Necrosis Factor, Type II, pubmed-meshheading:16369894-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16369894-Tooth, pubmed-meshheading:16369894-Tooth Movement, pubmed-meshheading:16369894-Tumor Necrosis Factor-alpha
pubmed:year
2006
pubmed:articleTitle
Experimental model of tooth movement by orthodontic force in mice and its application to tumor necrosis factor receptor-deficient mice.
pubmed:affiliation
Division of Oral Pathology and Bone Metabolism, Department of Developmental and Reconstructive Medicine, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't