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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-21
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pubmed:abstractText |
Abstract Cortactin is an F-actin-associated protein which interacts with the postsynaptic scaffolding protein Shank at the SH3 domain and is localized within the dendritic spine in the mouse neuron. Green fluorescent protein (GFP)-based time-lapse imaging revealed cortactin redistribution from dendritic cytoplasm to postsynaptic sites by application of brain-derived neurotrophic factor (BDNF). This response was mediated by mitogen-activated protein (MAP) kinase activation and was dependent on the C-terminal SH3 domain. In contrast, activation of N-methyl-D-aspartate (NMDA) receptors induced loss of cortactin from postsynaptic sites. This NMDA-dependent redistribution was blocked by an Src family kinase inhibitor. Conversely, increasing Src family kinase activity induced cortactin phosphorylation and loss of cortactin from the postsynaptic sites. Finally, blocking of endogenous BDNF reduced the amount of cortactin at the postsynaptic sites and an NMDA receptor antagonist prevented this reduction. These results indicate the importance of counterbalance between BDNF and NMDA receptor-mediated signalling in the reorganization of the postsynaptic actin cytoskeleton during neuronal development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/AG 1879,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cortactin,
http://linkedlifedata.com/resource/pubmed/chemical/Depsipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dual-Specificity Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Homer protein,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkB,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Slc17a7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/dual specificity phosphatase 12,
http://linkedlifedata.com/resource/pubmed/chemical/jasplakinolide
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2985-94
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16367765-2-Amino-5-phosphonovalerate,
pubmed-meshheading:16367765-Animals,
pubmed-meshheading:16367765-Antibodies,
pubmed-meshheading:16367765-Blotting, Western,
pubmed-meshheading:16367765-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:16367765-Carrier Proteins,
pubmed-meshheading:16367765-Cells, Cultured,
pubmed-meshheading:16367765-Cortactin,
pubmed-meshheading:16367765-Depsipeptides,
pubmed-meshheading:16367765-Drug Interactions,
pubmed-meshheading:16367765-Dual-Specificity Phosphatases,
pubmed-meshheading:16367765-Embryo, Mammalian,
pubmed-meshheading:16367765-Enzyme Inhibitors,
pubmed-meshheading:16367765-Excitatory Amino Acid Agonists,
pubmed-meshheading:16367765-Excitatory Amino Acid Antagonists,
pubmed-meshheading:16367765-Gene Expression Regulation,
pubmed-meshheading:16367765-Green Fluorescent Proteins,
pubmed-meshheading:16367765-Guanylate Kinase,
pubmed-meshheading:16367765-Hippocampus,
pubmed-meshheading:16367765-Hydrogen Peroxide,
pubmed-meshheading:16367765-Immunohistochemistry,
pubmed-meshheading:16367765-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16367765-Membrane Proteins,
pubmed-meshheading:16367765-Mice,
pubmed-meshheading:16367765-Models, Biological,
pubmed-meshheading:16367765-Mutagenesis,
pubmed-meshheading:16367765-Mutation,
pubmed-meshheading:16367765-N-Methylaspartate,
pubmed-meshheading:16367765-Neurons,
pubmed-meshheading:16367765-Phosphoprotein Phosphatases,
pubmed-meshheading:16367765-Pyrimidines,
pubmed-meshheading:16367765-Receptor, trkB,
pubmed-meshheading:16367765-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:16367765-Synapses,
pubmed-meshheading:16367765-Time Factors,
pubmed-meshheading:16367765-Transfection,
pubmed-meshheading:16367765-Vesicular Glutamate Transport Protein 1,
pubmed-meshheading:16367765-src Homology Domains
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pubmed:year |
2005
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pubmed:articleTitle |
Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity.
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pubmed:affiliation |
Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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