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rdf:type |
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lifeskim:mentions |
umls-concept:C0302600,
umls-concept:C1150587,
umls-concept:C1257792,
umls-concept:C1314939,
umls-concept:C1366876,
umls-concept:C1367731,
umls-concept:C1565860,
umls-concept:C1704259,
umls-concept:C1705323,
umls-concept:C1705632,
umls-concept:C1705987,
umls-concept:C1833235
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-20
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pubmed:abstractText |
Cyclooxygenase-2 (COX-2) is induced by hypoxic stimuli and is also involved in the process of angiogenesis. We previously demonstrated that vascular endothelial growth factor (VEGF) is one of the principal factors produced by hypoxic myocytes and is responsible for the induction of COX-2 expression in endothelial cells. Yet the signaling pathways by which VEGF modulates COX-2 gene expression are still less well defined. We therefore examined the regulation of VEGF-induced COX-2 expression by the mitogen-activated protein kinase (MAPK) family in endothelial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthracenes,
http://linkedlifedata.com/resource/pubmed/chemical/Butadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/U 0126,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/anthra(1,9-cd)pyrazol-6(2H)-one,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
512-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16336951-Anthracenes,
pubmed-meshheading:16336951-Butadienes,
pubmed-meshheading:16336951-Cells, Cultured,
pubmed-meshheading:16336951-Cyclooxygenase 2,
pubmed-meshheading:16336951-Endothelial Cells,
pubmed-meshheading:16336951-Endothelium, Vascular,
pubmed-meshheading:16336951-Gene Deletion,
pubmed-meshheading:16336951-Humans,
pubmed-meshheading:16336951-Imidazoles,
pubmed-meshheading:16336951-MAP Kinase Kinase 4,
pubmed-meshheading:16336951-Membrane Proteins,
pubmed-meshheading:16336951-Neovascularization, Physiologic,
pubmed-meshheading:16336951-Nitriles,
pubmed-meshheading:16336951-Nitrobenzenes,
pubmed-meshheading:16336951-Phosphorylation,
pubmed-meshheading:16336951-Pyridines,
pubmed-meshheading:16336951-RNA, Small Interfering,
pubmed-meshheading:16336951-Signal Transduction,
pubmed-meshheading:16336951-Sulfonamides,
pubmed-meshheading:16336951-Vascular Endothelial Growth Factor A,
pubmed-meshheading:16336951-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.
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pubmed:affiliation |
Division of Cardiology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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