Source:http://linkedlifedata.com/resource/pubmed/id/16272353
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2005-11-7
|
| pubmed:abstractText |
Lung transplantation is a therapeutic option for a number of end-stage pulmonary disorders. Early lung allograft dysfunction (ischemia-reperfusion injury) continues to be the most common cause of early mortality after lung transplantation and a significant risk factor for the development of bronchiolitis obliterans syndrome. Ischemia-reperfusion injury is characterized histopathologically by lung edema and a neutrophil predominate leukocyte extravasation. The specific mechanism(s) that recruit leukocytes to the lung during post-lung transplantation ischemia-reperfusion injury have not been fully elucidated. Because the ELR+ CXC chemokines are potent neutrophil chemoattractants, we investigated their role during post-lung transplantation ischemic-reperfusion injury. We found elevated levels of multiple ELR+ CXC chemokines in human bronchoalveolar lavage fluid from patients with ischemia-reperfusion injury. Proof of concept studies using a rat orthotopic lung transplantation model of "cold" ischemic-reperfusion injury demonstrated an increase in lung graft neutrophil sequestration and injury. In addition, lung expression of CXCL1, CXCL2/3, and their shared receptor CXCR2 paralleled lung neutrophil infiltration and injury. Importantly, inhibition of CXCR2/CXCR2 ligand interactions in vivo led to a marked reduction in lung neutrophil sequestration and graft injury. Taken together these experiments support the notion that increased expression of ELR+ CXC chemokines and their interaction with CXCR2 plays an important role in the pathogenesis of post-lung transplantation cold ischemia-reperfusion injury.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-1767
|
| pubmed:author |
pubmed-author:ArdehaliAbbasA,
pubmed-author:BelperioJohn AJA,
pubmed-author:BurdickMarie DMD,
pubmed-author:GompertsBrigitte NBN,
pubmed-author:HongKurtK,
pubmed-author:KeaneMichael PMP,
pubmed-author:LynchJoseph PJP3rd,
pubmed-author:MestasJavierJ,
pubmed-author:RossDavid JDJ,
pubmed-author:SaggarRajanR,
pubmed-author:StrieterRobert MRM,
pubmed-author:XueYing YingYY,
pubmed-author:ZismanDavidD
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
175
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6931-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:16272353-Animals,
pubmed-meshheading:16272353-Base Sequence,
pubmed-meshheading:16272353-Case-Control Studies,
pubmed-meshheading:16272353-Chemokines, CXC,
pubmed-meshheading:16272353-DNA,
pubmed-meshheading:16272353-Disease Models, Animal,
pubmed-meshheading:16272353-Female,
pubmed-meshheading:16272353-Humans,
pubmed-meshheading:16272353-Ligands,
pubmed-meshheading:16272353-Lung,
pubmed-meshheading:16272353-Lung Injury,
pubmed-meshheading:16272353-Lung Transplantation,
pubmed-meshheading:16272353-Male,
pubmed-meshheading:16272353-Middle Aged,
pubmed-meshheading:16272353-Neutrophils,
pubmed-meshheading:16272353-Prospective Studies,
pubmed-meshheading:16272353-Rats,
pubmed-meshheading:16272353-Receptors, Interleukin-8B,
pubmed-meshheading:16272353-Reperfusion Injury
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury.
|
| pubmed:affiliation |
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA. jbelperio@mednet.ucla.edu
|
| pubmed:publicationType |
Journal Article
|