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pubmed-article:16271798pubmed:abstractTextCocaine is an addictive psychostimulant that induces fos and opioid gene expression by activating the dopamine receptors and the PKA pathways in dopamine D1 and a glutamate NMDA-dependent mechanisms in the striatum. In this study, we show that a single cocaine administration induces ERK phosphorylation in the caudate/putamen of Fischer rats. This increase in Phospho-ERK is diminished by pre-administration of SCH23390, or MK801 but not with pre-administration of eticlopride. Furthermore, this single cocaine administration does not alter the levels of phospho-CREB protein or CREB-DNA bindings in the caudate/putamen protein extracts but does increase phospho-Elk-1 protein levels in the same extracts.lld:pubmed
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pubmed-article:16271798pubmed:articleTitleCocaine induction of ERK proteins in dorsal striatum of Fischer rats.lld:pubmed
pubmed-article:16271798pubmed:affiliationDepartment of Psychology, Hunter College of The City University of New York, NY 10021, USA.lld:pubmed
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