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rdf:type |
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lifeskim:mentions |
umls-concept:C0009170,
umls-concept:C0033684,
umls-concept:C0034703,
umls-concept:C0109317,
umls-concept:C0205263,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C2333957
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pubmed:issue |
2
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pubmed:dateCreated |
2005-11-28
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pubmed:abstractText |
Cocaine is an addictive psychostimulant that induces fos and opioid gene expression by activating the dopamine receptors and the PKA pathways in dopamine D1 and a glutamate NMDA-dependent mechanisms in the striatum. In this study, we show that a single cocaine administration induces ERK phosphorylation in the caudate/putamen of Fischer rats. This increase in Phospho-ERK is diminished by pre-administration of SCH23390, or MK801 but not with pre-administration of eticlopride. Furthermore, this single cocaine administration does not alter the levels of phospho-CREB protein or CREB-DNA bindings in the caudate/putamen protein extracts but does increase phospho-Elk-1 protein levels in the same extracts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
134-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16271798-Animals,
pubmed-meshheading:16271798-Benzazepines,
pubmed-meshheading:16271798-Blotting, Western,
pubmed-meshheading:16271798-Cocaine,
pubmed-meshheading:16271798-Corpus Striatum,
pubmed-meshheading:16271798-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:16271798-Dizocilpine Maleate,
pubmed-meshheading:16271798-Dopamine Antagonists,
pubmed-meshheading:16271798-Dopamine Uptake Inhibitors,
pubmed-meshheading:16271798-Dose-Response Relationship, Drug,
pubmed-meshheading:16271798-Drug Interactions,
pubmed-meshheading:16271798-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:16271798-Enzyme Induction,
pubmed-meshheading:16271798-Excitatory Amino Acid Antagonists,
pubmed-meshheading:16271798-Gene Expression Regulation,
pubmed-meshheading:16271798-Male,
pubmed-meshheading:16271798-Mitogen-Activated Protein Kinases,
pubmed-meshheading:16271798-Phosphorylation,
pubmed-meshheading:16271798-Rats,
pubmed-meshheading:16271798-Rats, Inbred F344,
pubmed-meshheading:16271798-Salicylamides
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pubmed:year |
2005
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pubmed:articleTitle |
Cocaine induction of ERK proteins in dorsal striatum of Fischer rats.
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pubmed:affiliation |
Department of Psychology, Hunter College of The City University of New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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