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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-14
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pubmed:abstractText |
Human epidermal growth factor receptor 2 (HER2) is overexpressed in 25-30% of ovarian carcinoma cases and a correlation between increased HER2 expression and decreased survival has been demonstrated. HER2 is a ligand-less member of the HER family that functions as the preferred coreceptor for epidermal growth factor receptor (EGFR), HER3, and HER4.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2005 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2701-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16265675-Animals,
pubmed-meshheading:16265675-Antibodies, Monoclonal,
pubmed-meshheading:16265675-Blotting, Western,
pubmed-meshheading:16265675-Cell Line, Tumor,
pubmed-meshheading:16265675-Cell Proliferation,
pubmed-meshheading:16265675-Disease Models, Animal,
pubmed-meshheading:16265675-Female,
pubmed-meshheading:16265675-Growth Inhibitors,
pubmed-meshheading:16265675-Humans,
pubmed-meshheading:16265675-Mice,
pubmed-meshheading:16265675-Ovarian Neoplasms,
pubmed-meshheading:16265675-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16265675-Receptor, erbB-2,
pubmed-meshheading:16265675-Sampling Studies,
pubmed-meshheading:16265675-Sensitivity and Specificity,
pubmed-meshheading:16265675-Signal Transduction,
pubmed-meshheading:16265675-Transplantation, Heterologous
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pubmed:year |
2005
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pubmed:articleTitle |
2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth.
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pubmed:affiliation |
Division of Hematology/Oncology, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles, CA 90048, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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