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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-10-31
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pubmed:abstractText |
Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular calcium levels. Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation. Our results indicate that mutant PS2 inhibits normal neuronal cell differentiation and that RyR-mediated calcium overrelease may be a significant factor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Dantrolene,
http://linkedlifedata.com/resource/pubmed/chemical/Intermediate Filament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurofilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Presenilin-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ryanodine Receptor Calcium Release...,
http://linkedlifedata.com/resource/pubmed/chemical/nestin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0360-4012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2005 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
542-50
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16240390-Animals,
pubmed-meshheading:16240390-Blotting, Western,
pubmed-meshheading:16240390-Caffeine,
pubmed-meshheading:16240390-Calcium,
pubmed-meshheading:16240390-Cell Differentiation,
pubmed-meshheading:16240390-Cells, Cultured,
pubmed-meshheading:16240390-Cerebral Cortex,
pubmed-meshheading:16240390-Dantrolene,
pubmed-meshheading:16240390-Drug Interactions,
pubmed-meshheading:16240390-Embryo, Mammalian,
pubmed-meshheading:16240390-Extracellular Space,
pubmed-meshheading:16240390-Gene Expression Regulation,
pubmed-meshheading:16240390-Immunohistochemistry,
pubmed-meshheading:16240390-Intermediate Filament Proteins,
pubmed-meshheading:16240390-Membrane Proteins,
pubmed-meshheading:16240390-Mice,
pubmed-meshheading:16240390-Mice, Transgenic,
pubmed-meshheading:16240390-Mutation,
pubmed-meshheading:16240390-Nerve Tissue Proteins,
pubmed-meshheading:16240390-Neurofilament Proteins,
pubmed-meshheading:16240390-Neurons,
pubmed-meshheading:16240390-Phosphodiesterase Inhibitors,
pubmed-meshheading:16240390-Presenilin-2,
pubmed-meshheading:16240390-RNA, Messenger,
pubmed-meshheading:16240390-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16240390-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:16240390-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation.
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pubmed:affiliation |
College of Pharmacy, Chungbuk National University, Chungbuk, Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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