|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0024264,
umls-concept:C0027950,
umls-concept:C0030705,
umls-concept:C0206081,
umls-concept:C0439599,
umls-concept:C0442027,
umls-concept:C0456603,
umls-concept:C1280500,
umls-concept:C1413716,
umls-concept:C1444662,
umls-concept:C1456475,
umls-concept:C1456820
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-1-20
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|
pubmed:abstractText |
Low-dose flutamide-metformin (Flu-Met) with an oral contraceptive is a therapeutic option for women with hyperinsulinaemic hyperandrogenism. We questioned (i) whether Flu-Met maintains efficacy if given discontinuously; (ii) how the efficacy of discontinuous Flu-Met plus a transdermal contraceptive compares with Flu-Met plus oral contraceptive; and (iii) whether these treatments also lower circulating C-reactive protein (CRP) and tumour necrosis factor alpha (TNF-alpha) and the high neutrophil/lymphocyte ratio.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0268-1161
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
451-6
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:16239318-Administration, Cutaneous,
pubmed-meshheading:16239318-Adolescent,
pubmed-meshheading:16239318-Adult,
pubmed-meshheading:16239318-C-Reactive Protein,
pubmed-meshheading:16239318-Contraceptive Agents, Female,
pubmed-meshheading:16239318-Contraceptives, Oral,
pubmed-meshheading:16239318-Drug Therapy, Combination,
pubmed-meshheading:16239318-Female,
pubmed-meshheading:16239318-Flutamide,
pubmed-meshheading:16239318-Humans,
pubmed-meshheading:16239318-Hyperandrogenism,
pubmed-meshheading:16239318-Hyperinsulinism,
pubmed-meshheading:16239318-Leukocyte Count,
pubmed-meshheading:16239318-Lymphocytes,
pubmed-meshheading:16239318-Metformin,
pubmed-meshheading:16239318-Neutrophils,
pubmed-meshheading:16239318-Tumor Necrosis Factor-alpha
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-alpha and the neutrophil/lymphocyte ratio.
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|
pubmed:affiliation |
Endocrinology Unit and Hormonal Laboratory, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain. libanez@hsjdbcn.org
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
