Linked Life Data

16210906

Source:http://linkedlifedata.com/resource/pubmed/id/16210906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-10-7
pubmed:abstractText
The recent discovery that T cells recognize endogenous and foreign lipid and glycolipid molecules presented by CD1 proteins has brought a major contribution in the understanding of innate and adaptive immune response to certain harmless antigens and infectious pathogens. Among (glyco)lipid-reactive T cells, CD1d-restricted natural killer (NK) T cells represent a population of innate/memory lymphocytes that, upon stimulation, rapidly release important amounts of immunoregulatory cytokines that in turn can shape the acquired immune response in a Th1 or a Th2 direction. Here we review the general features of these cells as well as their diverse influence in various disease models. A particular emphasis will be placed on the role of NK T cells in the promotion of asthma, a typical Th2-related inflammatory disease. Moreover, recent studies suggest that NK T cells could also be important in the modulation of the host immune response during helminthic infections, generally associated with dominated Th2 responses. Our current understanding of the role and of the mode of NK T cell activation during the initial immunological events that lead to the promotion of Th2 responses will be discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1660-2242
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-27
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Role of the natural killer T lymphocytes in Th2 responses during allergic asthma and helminth parasitic diseases.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale, Unité 547, Institut Pasteur de Lille, Lille, France. francois.trottein@pasteur-lille.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't