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rdf:type |
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lifeskim:mentions |
umls-concept:C0014544,
umls-concept:C0017262,
umls-concept:C0025344,
umls-concept:C0034693,
umls-concept:C0038220,
umls-concept:C0185117,
umls-concept:C0205191,
umls-concept:C0205275,
umls-concept:C0210994,
umls-concept:C0596902,
umls-concept:C0879392,
umls-concept:C0919458,
umls-concept:C1332002,
umls-concept:C1412077,
umls-concept:C1561960,
umls-concept:C1704873,
umls-concept:C1948053,
umls-concept:C2347804,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2005-9-29
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pubmed:abstractText |
Overexpression of multidrug transporters may play a role in the development of pharmacoresistance by decreasing extracellular drug levels in the brain. However, it is not known whether overexpression is due to an initial insult or evolves more gradually because of recurrent spontaneous seizures. In the present study, we investigated the expression of different multidrug transporters during epileptogenesis in the rat. In addition, we determined whether these transporters affected phenytoin (PHT) distribution in the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phenytoin,
http://linkedlifedata.com/resource/pubmed/chemical/Probenecid,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1569-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16190927-ATP-Binding Cassette Transporters,
pubmed-meshheading:16190927-Animals,
pubmed-meshheading:16190927-Anticonvulsants,
pubmed-meshheading:16190927-Brain,
pubmed-meshheading:16190927-Chronic Disease,
pubmed-meshheading:16190927-Drug Resistance, Multiple,
pubmed-meshheading:16190927-Electric Stimulation,
pubmed-meshheading:16190927-Epilepsy,
pubmed-meshheading:16190927-Humans,
pubmed-meshheading:16190927-Male,
pubmed-meshheading:16190927-Membrane Transport Proteins,
pubmed-meshheading:16190927-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:16190927-Neoplasm Proteins,
pubmed-meshheading:16190927-Phenytoin,
pubmed-meshheading:16190927-Probenecid,
pubmed-meshheading:16190927-Rats,
pubmed-meshheading:16190927-Rats, Sprague-Dawley,
pubmed-meshheading:16190927-Recurrence,
pubmed-meshheading:16190927-Status Epilepticus,
pubmed-meshheading:16190927-Tissue Distribution
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pubmed:year |
2005
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pubmed:articleTitle |
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.
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pubmed:affiliation |
Epilepsy Institute of the Netherlands (SEIN), Heemstede, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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