Source:http://linkedlifedata.com/resource/pubmed/id/16177829
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2005-12-1
|
| pubmed:abstractText |
The stromal-derived factor-1 (SDF-1) chemokine gene encodes the only natural ligand for CXCR4, the coreceptor for the pathogenic X4 HIV-1 strains. A single-nucleotide polymorphism (SNP) in the 3' untranslated region (SDF1-3'A=rs1801157) of SDF-1 was reported to be protective against infection and progression in some, but not other, epidemiological studies. To identify additional alleles that may influence HIV-1 infection and progression to AIDS, nine SNPs (including rs1801157) spanning 20.2 kb in and around the SDF-1 gene were genotyped in over 3000 African American (AA) and European American (EA) participants enrolled in five longitudinal HIV-1/AIDS natural cohort studies. Six or five haplotypes were present at frequencies greater than 5% in AA or EA, respectively. Six of the nine SNPs occur on only one common haplotype (>5%), while the remaining three SNPs were found on multiple haplotypes, suggesting a complex history of recombination. Among EA, rs754618 was associated with an increased risk of infection (OR=1.50, P=0.03), while rs1801157 (=SDF1-3'A) was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). Significant associations to a single disease outcome were found for two SNPs and one haplotype in AA.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1466-4879
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
691-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16177829-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:16177829-Adolescent,
pubmed-meshheading:16177829-Adult,
pubmed-meshheading:16177829-African Americans,
pubmed-meshheading:16177829-Alleles,
pubmed-meshheading:16177829-Chemokine CXCL12,
pubmed-meshheading:16177829-Chemokines, CXC,
pubmed-meshheading:16177829-Child,
pubmed-meshheading:16177829-Cohort Studies,
pubmed-meshheading:16177829-Disease Progression,
pubmed-meshheading:16177829-European Continental Ancestry Group,
pubmed-meshheading:16177829-Female,
pubmed-meshheading:16177829-Gene Frequency,
pubmed-meshheading:16177829-HIV Infections,
pubmed-meshheading:16177829-HIV-1,
pubmed-meshheading:16177829-Haplotypes,
pubmed-meshheading:16177829-Humans,
pubmed-meshheading:16177829-Longitudinal Studies,
pubmed-meshheading:16177829-Male,
pubmed-meshheading:16177829-Odds Ratio,
pubmed-meshheading:16177829-Polymorphism, Single Nucleotide,
pubmed-meshheading:16177829-Risk Factors,
pubmed-meshheading:16177829-Survival Analysis,
pubmed-meshheading:16177829-United States
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study.
|
| pubmed:affiliation |
SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|