| pubmed-article:16158332 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16158332 | lifeskim:mentions | umls-concept:C0009324 | lld:lifeskim |
| pubmed-article:16158332 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:16158332 | lifeskim:mentions | umls-concept:C0175631 | lld:lifeskim |
| pubmed-article:16158332 | lifeskim:mentions | umls-concept:C2827662 | lld:lifeskim |
| pubmed-article:16158332 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:16158332 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:16158332 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16158332 | pubmed:dateCreated | 2005-9-13 | lld:pubmed |
| pubmed-article:16158332 | pubmed:abstractText | The intensive research of recent years has suggested that the cause of ulcerative colitis (UC) involves a genetic predisposition to an uncontrolled or unbalanced immune response to luminal or epithelial antigens or against other external factors. Intercellular adhesion molecule-1 (ICAM-1) is pivotal for the influx of neutrophil granulocytes into colonic mucosa, and gene analyses have found polymorphisms in the gene encoding ICAM-1, indicating that changes in ICAM-1 function may be involved in the pathogenesis of UC. Clinical trials of the ICAM-1 antisense oligonucleotide Alicaforsen, which inhibits the synthesis of ICAM-1, have shown positive results in the treatment of patients with left-sided (distal) UC. In addition to emphasizing the central role of ICAM-1 in active stages of UC, the results provide hope for the development and introduction of a more specific and efficient treatment for UC than those currently available. This review discusses the results from studies on the expression of ICAM-1 in colonic tissue from patients with UC. | lld:pubmed |
| pubmed-article:16158332 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16158332 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16158332 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16158332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16158332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16158332 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16158332 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16158332 | pubmed:issn | 1023-3830 | lld:pubmed |
| pubmed-article:16158332 | pubmed:author | pubmed-author:VainerBB | lld:pubmed |
| pubmed-article:16158332 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16158332 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:16158332 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16158332 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16158332 | pubmed:pagination | 313-27 | lld:pubmed |
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| pubmed-article:16158332 | pubmed:meshHeading | pubmed-meshheading:16158332... | lld:pubmed |
| pubmed-article:16158332 | pubmed:meshHeading | pubmed-meshheading:16158332... | lld:pubmed |
| pubmed-article:16158332 | pubmed:meshHeading | pubmed-meshheading:16158332... | lld:pubmed |
| pubmed-article:16158332 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16158332 | pubmed:articleTitle | Intercellular adhesion molecule-1 (ICAM-1) in ulcerative colitis: presence, visualization, and significance. | lld:pubmed |
| pubmed-article:16158332 | pubmed:affiliation | Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark. ben.vainer@rh.hosp.dk | lld:pubmed |
| pubmed-article:16158332 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:3383 | entrezgene:pubmed | pubmed-article:16158332 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16158332 | lld:entrezgene |
| lhgdn:association:19773 | lhgdn:found_in | pubmed-article:16158332 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16158332 | lld:pubmed |
