| pubmed-article:16148028 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C1517377 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C0041485 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C0597538 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C1518062 | lld:lifeskim |
| pubmed-article:16148028 | lifeskim:mentions | umls-concept:C0074992 | lld:lifeskim |
| pubmed-article:16148028 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:16148028 | pubmed:dateCreated | 2005-11-1 | lld:pubmed |
| pubmed-article:16148028 | pubmed:abstractText | The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) transduces signals from S1P that mediate thymocyte emigration, T cell transmigration of lymph nodes, and T cell chemotaxis in tissues. Alterations in expression of functional S1P1 receptors by lymphocytes are the major mechanisms controlling their responses to S1P and were thought to be solely a consequence of the balance between surface down-regulation and insertion. However, results now show that lack of sulfation of tyrosines 19 and 22 of the extracellular N terminus of S1P1 diminishes high-affinity S1P binding and decreases S1P signaling of T cell migration and other functions. Non-sulfatable mutant (Y19,22F)S1P1 endows T cells with lower-affinity binding of [32P]S1P than wild-type S1P1 and transduces lesser effects of S1P on chemotaxis, chemokine-elicited chemotaxis, and T cell receptor-mediated proliferation and cytokine generation. Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P. Tyrosine sulfation of S1P1 may be a major controller of S1P effects on T cell traffic. | lld:pubmed |
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| pubmed-article:16148028 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16148028 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16148028 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16148028 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16148028 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:16148028 | pubmed:author | pubmed-author:GoetzlEdward... | lld:pubmed |
| pubmed-article:16148028 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:16148028 | pubmed:author | pubmed-author:HuangMei-Chua... | lld:pubmed |
| pubmed-article:16148028 | pubmed:author | pubmed-author:FiegerClaudia... | lld:pubmed |
| pubmed-article:16148028 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16148028 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:16148028 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16148028 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16148028 | pubmed:pagination | 1926-8 | lld:pubmed |
| pubmed-article:16148028 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16148028 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16148028 | pubmed:articleTitle | Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | lld:pubmed |
| pubmed-article:16148028 | pubmed:affiliation | Department of Anatomy, University of California, San Francisco, California 94143-0711, USA. | lld:pubmed |
| pubmed-article:16148028 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16148028 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16148028 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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