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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2005-11-1
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pubmed:abstractText |
The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) transduces signals from S1P that mediate thymocyte emigration, T cell transmigration of lymph nodes, and T cell chemotaxis in tissues. Alterations in expression of functional S1P1 receptors by lymphocytes are the major mechanisms controlling their responses to S1P and were thought to be solely a consequence of the balance between surface down-regulation and insertion. However, results now show that lack of sulfation of tyrosines 19 and 22 of the extracellular N terminus of S1P1 diminishes high-affinity S1P binding and decreases S1P signaling of T cell migration and other functions. Non-sulfatable mutant (Y19,22F)S1P1 endows T cells with lower-affinity binding of [32P]S1P than wild-type S1P1 and transduces lesser effects of S1P on chemotaxis, chemokine-elicited chemotaxis, and T cell receptor-mediated proliferation and cytokine generation. Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P. Tyrosine sulfation of S1P1 may be a major controller of S1P effects on T cell traffic.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-11733580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-11847099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-12037142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-12069842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-12370333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-12401804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-12468451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-14500646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-15578083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-15657295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-15699128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-3862121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-9501187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16148028-9660876
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysophospholipid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysosphingolipid,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1530-6860
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1926-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16148028-Amino Acid Sequence,
pubmed-meshheading:16148028-Animals,
pubmed-meshheading:16148028-Blotting, Western,
pubmed-meshheading:16148028-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16148028-Cell Movement,
pubmed-meshheading:16148028-Cell Proliferation,
pubmed-meshheading:16148028-Chemotaxis,
pubmed-meshheading:16148028-Cytokines,
pubmed-meshheading:16148028-Dose-Response Relationship, Drug,
pubmed-meshheading:16148028-Down-Regulation,
pubmed-meshheading:16148028-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16148028-Humans,
pubmed-meshheading:16148028-Immunoprecipitation,
pubmed-meshheading:16148028-Interferon-gamma,
pubmed-meshheading:16148028-Jurkat Cells,
pubmed-meshheading:16148028-Lipid Metabolism,
pubmed-meshheading:16148028-Lipids,
pubmed-meshheading:16148028-Lymphatic Metastasis,
pubmed-meshheading:16148028-Lymphocytes,
pubmed-meshheading:16148028-Lysophospholipids,
pubmed-meshheading:16148028-Mice,
pubmed-meshheading:16148028-Models, Biological,
pubmed-meshheading:16148028-Molecular Sequence Data,
pubmed-meshheading:16148028-Mutation,
pubmed-meshheading:16148028-Protein Binding,
pubmed-meshheading:16148028-Protein Structure, Tertiary,
pubmed-meshheading:16148028-Receptors, Lysophospholipid,
pubmed-meshheading:16148028-Receptors, Lysosphingolipid,
pubmed-meshheading:16148028-Sequence Homology, Amino Acid,
pubmed-meshheading:16148028-Signal Transduction,
pubmed-meshheading:16148028-Sphingosine,
pubmed-meshheading:16148028-Spleen,
pubmed-meshheading:16148028-T-Lymphocytes,
pubmed-meshheading:16148028-Thymus Gland,
pubmed-meshheading:16148028-Transfection,
pubmed-meshheading:16148028-Tyrosine
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pubmed:year |
2005
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pubmed:articleTitle |
Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines.
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pubmed:affiliation |
Department of Anatomy, University of California, San Francisco, California 94143-0711, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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