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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030847,
umls-concept:C0030851,
umls-concept:C0039242,
umls-concept:C0040300,
umls-concept:C0205191,
umls-concept:C0529793,
umls-concept:C0757672,
umls-concept:C0936012,
umls-concept:C1280500,
umls-concept:C1515655
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pubmed:issue |
4 Pt 1
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|
pubmed:dateCreated |
2005-9-7
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pubmed:abstractText |
Conflicting information exists regarding the long-term efficacy of phosphodiesterase-5 (PDE5) inhibitor therapy for erectile dysfunction, particularly in regard to whether therapeutic resistance occurs. We investigated the erectile response, and cavernous PDE5 expression and activity after continuous long-term administration of sildenafil at verified therapeutic plasma concentrations, applying an in vivo rat model of age related erectile dysfunction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1493-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16145478-3',5'-Cyclic-GMP Phosphodiesterases,
pubmed-meshheading:16145478-Animals,
pubmed-meshheading:16145478-Drug Resistance,
pubmed-meshheading:16145478-Erectile Dysfunction,
pubmed-meshheading:16145478-Lung,
pubmed-meshheading:16145478-Male,
pubmed-meshheading:16145478-Penile Erection,
pubmed-meshheading:16145478-Piperazines,
pubmed-meshheading:16145478-Purines,
pubmed-meshheading:16145478-Rats,
pubmed-meshheading:16145478-Rats, Inbred F344,
pubmed-meshheading:16145478-Sulfones
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pubmed:year |
2005
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pubmed:articleTitle |
In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: no tachyphylaxis effect.
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pubmed:affiliation |
Department of Urology and Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA. bsmusicki@jhmi.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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