|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008902,
umls-concept:C0026764,
umls-concept:C0030705,
umls-concept:C0040649,
umls-concept:C0040715,
umls-concept:C0205160,
umls-concept:C1413172,
umls-concept:C1520599,
umls-concept:C1521991,
umls-concept:C1880022,
umls-concept:C1979963,
umls-concept:C2003903
|
|
pubmed:issue |
29
|
|
pubmed:dateCreated |
2005-10-7
|
|
pubmed:abstractText |
The deregulation of CCND1, CCND2 and CCND3 genes represents a common event in multiple myeloma (MM). A recently proposed classification grouped MM patients into five classes on the basis of their cyclin D expression profiles and the presence of the main translocations involving the immunoglobulin heavy chain locus (IGH) at 14q32. In this study, we provide a molecular characterization of the identified translocations/cyclins (TC) groups.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
pubmed-author:AgnelliLucaL,
pubmed-author:BaldiniLucaL,
pubmed-author:BicciatoSilvioS,
pubmed-author:CalleaVincenzoV,
pubmed-author:FabrisSoniaS,
pubmed-author:IntiniDanielaD,
pubmed-author:LombardiLuigiaL,
pubmed-author:MattioliMichelaM,
pubmed-author:MorabitoFortunatoF,
pubmed-author:NeriAntoninoA,
pubmed-author:VerdelliDonataD
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7296-306
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16129847-Adult,
pubmed-meshheading:16129847-Aged,
pubmed-meshheading:16129847-Aged, 80 and over,
pubmed-meshheading:16129847-Cyclin D1,
pubmed-meshheading:16129847-Female,
pubmed-meshheading:16129847-Gene Expression,
pubmed-meshheading:16129847-Gene Expression Profiling,
pubmed-meshheading:16129847-Humans,
pubmed-meshheading:16129847-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16129847-Male,
pubmed-meshheading:16129847-Middle Aged,
pubmed-meshheading:16129847-Multiple Myeloma,
pubmed-meshheading:16129847-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16129847-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16129847-Translocation, Genetic
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations.
|
|
pubmed:affiliation |
UO Ematologia 2, Centro G. Marcora, Ospedale Maggiore Policlinico IRCCS, Dipartimento Scienze Mediche, Università degli Studi di Milano, Via Francesco Sforza 35, 20122 Milano, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
