Linked Life Data

16109807

Source:http://linkedlifedata.com/resource/pubmed/id/16109807

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-14
pubmed:abstractText
ANG II applied to the interstitial space influences carbohydrate and lipid metabolism in a tissue-specific fashion. Thus endogenous ANG II may have a tonic effect on tissue metabolism that could be reversed with ANG II type 1 (AT1) receptor blockade, particularly during adrenergic stimulation. We studied 14 obese men. They were treated for 10 days with the AT1 receptor blocker irbesartan or with placebo in a double-blind and crossover fashion. At the end of each treatment period, we assessed skeletal muscle and adipose tissue metabolism using the microdialysis technique. The ethanol dilution technique was applied to follow changes in tissue blood flow. Measurements were obtained at baseline and during application of incremental isoproterenol concentrations through the microdialysis catheter. Blood pressure decreased from 133 +/- 3/84 +/- 3 to 128 +/- 3/79 +/- 2 mmHg for systolic and diastolic blood, respectively (P = 0.02 and 0.006, respectively) with AT1 receptor blockade. Isoproterenol perfusion caused a dose-dependent increase in dialysate glycerol in adipose tissue and in skeletal muscle. Irbesartan slightly reduced the isoproterenol-induced glycerol response in adipose tissue (P < 0.05 by ANOVA). Ethanol ratio, interstitial glucose supply, and lactate production in adipose tissue and skeletal muscle were similar with placebo and irbesartan. We conclude that AT1 receptor blockade in obese men does not reveal a major tonic ANG II effect on interstitial glucose supply, lipolysis, or glycolysis in skeletal muscle, either at rest or during beta-adrenergic stimulation. Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R219-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16109807-Adipose Tissue, pubmed-meshheading:16109807-Adult, pubmed-meshheading:16109807-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:16109807-Biphenyl Compounds, pubmed-meshheading:16109807-Cross-Over Studies, pubmed-meshheading:16109807-Dose-Response Relationship, Drug, pubmed-meshheading:16109807-Energy Metabolism, pubmed-meshheading:16109807-Ethanol, pubmed-meshheading:16109807-Glycerol, pubmed-meshheading:16109807-Humans, pubmed-meshheading:16109807-Isoproterenol, pubmed-meshheading:16109807-Lactic Acid, pubmed-meshheading:16109807-Male, pubmed-meshheading:16109807-Microdialysis, pubmed-meshheading:16109807-Muscle, Skeletal, pubmed-meshheading:16109807-Obesity, pubmed-meshheading:16109807-Pyruvic Acid, pubmed-meshheading:16109807-Receptor, Angiotensin, Type 1, pubmed-meshheading:16109807-Tetrazoles
pubmed:year
2006
pubmed:articleTitle
Influences of AT1 receptor blockade on tissue metabolism in obese men.
pubmed:affiliation
Franz Volhard Clinical Research Center, Haus 129, Charité Campus Buch, Wiltbergstr. 50, 13125 Berlin, Germany.
pubmed:publicationType
Journal Article, Controlled Clinical Trial, Research Support, Non-U.S. Gov't