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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-8-29
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pubmed:abstractText |
The regulatory sequences of the Drosophila ACP65A cuticle gene were analyzed in vivo in transgenic flies, using both fusion genes constructs and transposase-mediated deletions within a P element containing ACP65A regulatory sequences fused to the lacZ gene (deletion scanning). The sequences located between -594 and +161 are sufficient to confer both temporal and spatial expression specificities, indicating the presence of tissue-specific enhancers and response elements to hormone-induced factors. In addition, timing of expression and tissue-specificity appear to be controlled by distinct cis-regulatory elements, which suggests the existence of independent hormonal and tissue-specific signaling pathways. Gain and loss of function studies also implicate DHR38, the Drosophila homolog of the vertebrate NGFI-B-type nuclear receptors, as an important activator of the ACP65A gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hr38 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/cuticle proteins, insects
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1526-954X
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2005 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-27
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16106360-Animals,
pubmed-meshheading:16106360-Animals, Genetically Modified,
pubmed-meshheading:16106360-Base Sequence,
pubmed-meshheading:16106360-Crosses, Genetic,
pubmed-meshheading:16106360-DNA-Binding Proteins,
pubmed-meshheading:16106360-Drosophila,
pubmed-meshheading:16106360-Drosophila Proteins,
pubmed-meshheading:16106360-Female,
pubmed-meshheading:16106360-Gene Expression Regulation,
pubmed-meshheading:16106360-Insect Proteins,
pubmed-meshheading:16106360-Male,
pubmed-meshheading:16106360-Nuclear Receptor Subfamily 4, Group A, Member 1,
pubmed-meshheading:16106360-Pupa,
pubmed-meshheading:16106360-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:16106360-Receptors, Steroid,
pubmed-meshheading:16106360-Sequence Deletion,
pubmed-meshheading:16106360-Transcription, Genetic,
pubmed-meshheading:16106360-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
The Drosophila ACP65A cuticle gene: deletion scanning analysis of cis-regulatory sequences and regulation by DHR38.
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pubmed:affiliation |
UMR CNRS 5548 Développement-Communication Chimique, Université de Bourgogne, Faculté des Sciences Gabriel, Dijon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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