|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2005-8-16
|
|
pubmed:abstractText |
Dosing of the microemulsion formulation of cyclosporine (Neoral) is conventionally based on trough levels (C(0)). However, experience in renal transplantation has shown that cyclosporine exposure during the absorption phase (AUC(0-4)) is critical for optimizing immunosuppression, and that cyclosporine (CsA) concentration at 2 hours post-dose (C(2)) shows the closest correlation with AUC(0-4). This study evaluated whether C(2) values correlate more closely with AUC(0-4) than C(0) in lung transplant patients.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1053-2498
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1076-80
|
|
pubmed:meshHeading |
pubmed-meshheading:16102443-Adult,
pubmed-meshheading:16102443-Aged,
pubmed-meshheading:16102443-Area Under Curve,
pubmed-meshheading:16102443-Biological Markers,
pubmed-meshheading:16102443-Cyclosporine,
pubmed-meshheading:16102443-Dose-Response Relationship, Drug,
pubmed-meshheading:16102443-Drug Administration Schedule,
pubmed-meshheading:16102443-Female,
pubmed-meshheading:16102443-Graft Rejection,
pubmed-meshheading:16102443-Graft Survival,
pubmed-meshheading:16102443-Humans,
pubmed-meshheading:16102443-Immunosuppressive Agents,
pubmed-meshheading:16102443-Lung Transplantation,
pubmed-meshheading:16102443-Male,
pubmed-meshheading:16102443-Middle Aged,
pubmed-meshheading:16102443-Monitoring, Physiologic,
pubmed-meshheading:16102443-Predictive Value of Tests,
pubmed-meshheading:16102443-Prognosis,
pubmed-meshheading:16102443-Prospective Studies,
pubmed-meshheading:16102443-Risk Assessment,
pubmed-meshheading:16102443-Sensitivity and Specificity,
pubmed-meshheading:16102443-Transplantation Immunology
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Monitoring C2 level predicts exposure in maintenance lung transplant patients receiving the microemulsion formulation of cyclosporine (Neoral).
|
|
pubmed:affiliation |
Department of Cardio-Thoracic Surgery, University Hospital, Vienna, Austria. p.jaksch@lunge.at
|
|
pubmed:publicationType |
Journal Article
|
