| pubmed-article:16085674 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0109317 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1705767 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1711178 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0003240 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1366882 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1150579 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1333340 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C1705791 | lld:lifeskim |
| pubmed-article:16085674 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:16085674 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16085674 | pubmed:dateCreated | 2005-12-13 | lld:pubmed |
| pubmed-article:16085674 | pubmed:abstractText | Macrolide antibiotics decrease proinflammatory cytokine production in airway cells from subjects with chronic airway inflammation. However, in subjects with chronic obstructive pulmonary disease, short-term azithromycin (AZM) therapy causes a transient early increase in the blood neutrophil oxidative burst followed by a decrease in inflammatory markers with longer administration. We studied the effects of clarithromycin (CAM) and AZM on proinflammatory cytokine production from normal human bronchial epithelial (NHBE) cells. CAM decreased IL-8 over the first 6 h and then significantly increased interleukin (IL)-8 at 12-72 h after exposure (P < 0.0001). AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P < 0.001). PD-98059, an inhibitor of MAP kinase/ERK kinase, inhibited CAM-induced IL-8 (P < 0.0001) and GM-CSF (P < 0.01) release. The p38 MAP kinase inhibitor SB-203580 increased CAM-induced IL-8 release (P < 0.001), and the c-jun NH2-terminal kinase inhibitor SP-600125 had no effect on IL-8. At 120 min and 6 h, CAM increased phospho-ERK1/2 (pERK) but not phospho-p38 or phospho-JNK. Over the first 90 min, CAM at 10 microg/ml inhibited pERK and then increased pERK in parallel with measured IL-8 secretion. After daily CAM exposure for 5 days, both IL-8 and pERK returned to baseline. The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion. These results suggest that macrolide antibiotics can differentially modulate proinflammatory cytokine secretion in NHBE cells, in part through ERK. | lld:pubmed |
| pubmed-article:16085674 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16085674 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16085674 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16085674 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16085674 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:16085674 | pubmed:author | pubmed-author:FosterGregory... | lld:pubmed |
| pubmed-article:16085674 | pubmed:author | pubmed-author:ShinkaiMasaha... | lld:pubmed |
| pubmed-article:16085674 | pubmed:author | pubmed-author:RubinBruce... | lld:pubmed |
| pubmed-article:16085674 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16085674 | pubmed:volume | 290 | lld:pubmed |
| pubmed-article:16085674 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16085674 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16085674 | pubmed:pagination | L75-85 | lld:pubmed |
| pubmed-article:16085674 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:meshHeading | pubmed-meshheading:16085674... | lld:pubmed |
| pubmed-article:16085674 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16085674 | pubmed:articleTitle | Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. | lld:pubmed |
| pubmed-article:16085674 | pubmed:affiliation | Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1081, USA. | lld:pubmed |
| pubmed-article:16085674 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16085674 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16085674 | lld:pubmed |
