Linked Life Data

16084720

Source:http://linkedlifedata.com/resource/pubmed/id/16084720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2005-8-22
pubmed:abstractText
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1' group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-alpha production and a collagen-induced arthritis model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4345-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16084720-ADAM Proteins, pubmed-meshheading:16084720-Animals, pubmed-meshheading:16084720-Biological Availability, pubmed-meshheading:16084720-Caspases, pubmed-meshheading:16084720-Cell Line, pubmed-meshheading:16084720-Crystallography, X-Ray, pubmed-meshheading:16084720-Cysteine Proteinase Inhibitors, pubmed-meshheading:16084720-Dogs, pubmed-meshheading:16084720-Humans, pubmed-meshheading:16084720-Hydroxamic Acids, pubmed-meshheading:16084720-Inhibitory Concentration 50, pubmed-meshheading:16084720-Lipopolysaccharides, pubmed-meshheading:16084720-Mice, pubmed-meshheading:16084720-Molecular Structure, pubmed-meshheading:16084720-Monocytes, pubmed-meshheading:16084720-Rats, pubmed-meshheading:16084720-Species Specificity, pubmed-meshheading:16084720-Structure-Activity Relationship, pubmed-meshheading:16084720-Sulfonamides, pubmed-meshheading:16084720-Tumor Necrosis Factor-alpha
pubmed:year
2005
pubmed:articleTitle
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
pubmed:affiliation
Wyeth Research, 401N. Middletown Road, Pearl River, NY 10965, USA. levinji@wyeth.com
pubmed:publicationType
Journal Article