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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-8-5
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pubmed:abstractText |
Hemopoietic stem and progenitor cells ordinarily residing within bone marrow are released into the circulation following G-CSF administration. Such mobilization has a great clinical impact on hemopoietic stem cell transplantation. Underlying mechanisms are incompletely understood, but may involve G-CSF-induced modulation of chemokines, adhesion molecules, and proteolytic enzymes. We studied G-CSF-induced mobilization of CD34+ CD10+ CD19- Lin- and CD34+ CD10+ CD19+ Lin- cells (early B and pro-B cells, respectively). These mobilized lymphoid populations could differentiate only into B/NK cells or B cells equivalent to their marrow counterparts. Mobilized lymphoid progenitors expressed lymphoid- but not myeloid-related genes including the G-CSF receptor gene, and displayed the same pattern of Ig rearrangement status as their bone marrow counterparts. Decreased expression of VLA-4 and CXCR-4 on mobilized lymphoid progenitors as well as multipotent and myeloid progenitors indicated lineage-independent involvement of these molecules in G-CSF-induced mobilization. The results suggest that by acting through multiple trans-acting signals, G-CSF can mobilize not only myeloid-committed populations but a variety of resident marrow cell populations including lymphoid progenitors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:HaradaMineM,
pubmed-author:HenzanHidehoH,
pubmed-author:ImamuraRieR,
pubmed-author:InabaShoichiS,
pubmed-author:IshikawaFumihikoF,
pubmed-author:KamezakiKenjiroK,
pubmed-author:KatoKojiK,
pubmed-author:MiyamotoToshihiroT,
pubmed-author:NagafujiKojiK,
pubmed-author:NumataAkihikoA,
pubmed-author:OkamuraTakashiT,
pubmed-author:SataMichioM,
pubmed-author:TakaseKenK,
pubmed-author:YoshimotoGoichiG
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2647-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16081841-Animals,
pubmed-meshheading:16081841-Bone Marrow Cells,
pubmed-meshheading:16081841-Cell Adhesion Molecules,
pubmed-meshheading:16081841-Cell Culture Techniques,
pubmed-meshheading:16081841-Cell Differentiation,
pubmed-meshheading:16081841-Cell Lineage,
pubmed-meshheading:16081841-Flow Cytometry,
pubmed-meshheading:16081841-Gene Expression Profiling,
pubmed-meshheading:16081841-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:16081841-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:16081841-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:16081841-Hematopoietic Stem Cells,
pubmed-meshheading:16081841-Humans,
pubmed-meshheading:16081841-Immunoglobulin Heavy Chains,
pubmed-meshheading:16081841-Immunophenotyping,
pubmed-meshheading:16081841-Lymphocyte Count,
pubmed-meshheading:16081841-Lymphocyte Subsets,
pubmed-meshheading:16081841-Mice,
pubmed-meshheading:16081841-Mice, Inbred NOD,
pubmed-meshheading:16081841-Mice, Knockout,
pubmed-meshheading:16081841-Mice, SCID,
pubmed-meshheading:16081841-Myeloid Progenitor Cells
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pubmed:year |
2005
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pubmed:articleTitle |
Mobilization of human lymphoid progenitors after treatment with granulocyte colony-stimulating factor.
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pubmed:affiliation |
Blood Transfusion Service, Kyushu University Hospital, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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