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rdf:type |
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lifeskim:mentions |
umls-concept:C0034833,
umls-concept:C0038477,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0243192,
umls-concept:C0679622,
umls-concept:C1522538,
umls-concept:C1553032,
umls-concept:C1609964,
umls-concept:C1709060,
umls-concept:C1883254
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pubmed:issue |
16
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pubmed:dateCreated |
2005-8-4
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pubmed:abstractText |
Tanaproget represents a potential first-in-class nonsteroidal PR agonist for contraception with improved safety and side effect profiles versus currently available steroidal oral contraceptives. Additional SAR, biological activity, and structural information from a tanaproget/hPR-LBD (hPR-LBD = human progesterone receptor ligand binding domain) cocrystal structure will also be presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazines,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptive Agents, Female,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Thiones,
http://linkedlifedata.com/resource/pubmed/chemical/tanoproget
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BenderReinholdR,
pubmed-author:ChopraRajivR,
pubmed-author:CohenJeffJ,
pubmed-author:CollinsMark AMA,
pubmed-author:FensomeAndrewA,
pubmed-author:HudakValerieV,
pubmed-author:LockheadSusanS,
pubmed-author:MalakianKarlK,
pubmed-author:OllandAndreaA,
pubmed-author:SvensonKristineK,
pubmed-author:TerefenkoEugene AEA,
pubmed-author:UnwallaRay JRJ,
pubmed-author:WilhelmJames MJM,
pubmed-author:WinnekerRichard CRC,
pubmed-author:WolfromScottS,
pubmed-author:WrobelJayJ,
pubmed-author:ZhangPuwenP,
pubmed-author:ZhangZhimingZ,
pubmed-author:ZhuYuanY
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5092-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16078826-Alkaline Phosphatase,
pubmed-meshheading:16078826-Animals,
pubmed-meshheading:16078826-Area Under Curve,
pubmed-meshheading:16078826-Benzoxazines,
pubmed-meshheading:16078826-Binding, Competitive,
pubmed-meshheading:16078826-Cell Line, Tumor,
pubmed-meshheading:16078826-Contraceptive Agents, Female,
pubmed-meshheading:16078826-Decidua,
pubmed-meshheading:16078826-Female,
pubmed-meshheading:16078826-Half-Life,
pubmed-meshheading:16078826-Humans,
pubmed-meshheading:16078826-Ligands,
pubmed-meshheading:16078826-Molecular Structure,
pubmed-meshheading:16078826-Oxazines,
pubmed-meshheading:16078826-Protein Structure, Tertiary,
pubmed-meshheading:16078826-Pyrroles,
pubmed-meshheading:16078826-Rats,
pubmed-meshheading:16078826-Rats, Sprague-Dawley,
pubmed-meshheading:16078826-Receptors, Progesterone,
pubmed-meshheading:16078826-Structure-Activity Relationship,
pubmed-meshheading:16078826-Thiones
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
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pubmed:affiliation |
Chemical and Screening Sciences, Women's Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. fensoma@wyeth.com
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pubmed:publicationType |
Journal Article,
In Vitro
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