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pubmed:abstractText |
Studies on the development of the R7 photoreceptor in the Drosophila eye thus far have identified three genes that specifically affect this cell: sevenless, boss and sina. In each of these mutants the R7 precursor develops instead as the equatorial cone cell (EQC). We have isolated an enhancer trap line, H214, in which beta-galactosidase is primarily expressed in the R7 cell throughout its development. In mutations of sevenless, boss and sina, expression in H214 is initially reduced although still present in the R7 precursor and persists in the EQC into which it develops. The EQC in wild type never expresses lacZ in H214. This result is in contrast to that seen with other enhancer trap lines that display expression in R7, and indicates that some aspect of R7 differentiation is independent of the genetic pathway(s) involving sevenless, boss and sina.
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