Linked Life Data

1605595

Source:http://linkedlifedata.com/resource/pubmed/id/1605595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-7-14
pubmed:abstractText
The safety, pharmacokinetics, and distribution in tissue of an amphotericin B (AmB)-cholesteryl sulfate colloidal dispersion (ABCD) were compared with those of micellar amphotericin B-deoxycholate (m-AmB). Dogs received 14 daily injections of ABCD (0.6 to 10 mg/kg of body weight per day) or m-AmB (0.6 mg/kg/day). Safety was evaluated by monitoring body weight, hematology, clinical chemistry, and urinalysis during the study and by microscopic examination of tissues at the time of necropsy (day 16). AmB concentrations in plasma were measured in some groups on days 1, 7, and 14 and in necropsy tissue samples. ABCD produced a spectrum of toxic effects in the kidneys, gut, and liver similar to those of m-AmB, but ABCD was eightfold safer than m-AmB. The highest tolerated dose of ABCD (5.0 mg/kg/day) produced effects similar to those of m-AmB (0.6 mg/kg/day). ABCD produced lower concentrations in plasma than an equal dose of m-AmB did. Clearances on days 7 and 14 were higher for ABCD (304 and 295 ml/h.kg) than they were for m-AmB (67 and 53 ml/h.kg). Concentrations in plasma reached steady state after ABCD administration, but they increased after repeated dosing with m-AmB. Diurnal fluctuations in AmB concentrations in plasma were observed 4 to 8 h after the time of dosing. ABCD resulted in lower AmB concentrations in tissue than m-AmB did, except in the reticuloendothelial system. Up to 90% of AmB administered as ABCD was recovered from the liver and spleen on day 16. Reduced drug levels in the kidneys and gut correlated with reduced indications of toxicity in these organs after ABCD administration. Although ABCD increased concentrations of AmB in the reticuloendothelial system, increased toxicity was not observed in these organs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-1929263, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2185689, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2313133, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2401582, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2658785, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2693111, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2698855, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-2926162, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-3967472, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-3973417, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-4043596, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-501147, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-6399857, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-6517539, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-6882617, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-7077097, http://linkedlifedata.com/resource/pubmed/commentcorrection/1605595-7097552
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-307
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Relationship of pharmacokinetics and drug distribution in tissue to increased safety of amphotericin B colloidal dispersion in dogs.
pubmed:affiliation
Liposome Technology, Inc., Menlo Park, California 94025, USA.
pubmed:publicationType
Journal Article, Comparative Study