| pubmed-article:16030130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0054961 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0282637 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:16030130 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:16030130 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16030130 | pubmed:dateCreated | 2005-7-27 | lld:pubmed |
| pubmed-article:16030130 | pubmed:abstractText | Synovial tissues are frequent sites of inflammatory disorders in which dendritic cells (DCs) may play an important role. This study examines potential antigen-presenting cells obtained from synovium-rich tissues (SRTs) by vascular perfusion of rat hind limbs with collagenase and further enzymatic digestion of the disarticulated hind paws in vitro. The three sub-populations of interest were: CD45+MHC IIhi, mainly CD11c+ and CD163-; CD45+MHC IIlo, mainly CD11c- and CD163+ and CD45+MHC II-, mainly CD11c- and CD163+. Expression of CD11c and CD163 correlated with ruffled cell-surface (CD11c+CD163-) and highly vacuolated cytoplasm (CD11c-CD163+), respectively. Culture of the CD45+CD163- sub-population in granulocyte macrophage colony-stimulating factor (GM-CSF) yielded CD45+MHC IIhi CD11c+CD163- cells with veiled morphology, while the large vacuolated cells that expressed CD163 resembled type A synoviocytes in both surface antigen phenotype and morphology. These results demonstrate that SRTs contain indeterminate cells that can differentiate into mature DCs in vitro in response to GM-CSF, plus mature synovial lining macrophages. | lld:pubmed |
| pubmed-article:16030130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16030130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16030130 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16030130 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:16030130 | pubmed:author | pubmed-author:ClelandLeslie... | lld:pubmed |
| pubmed-article:16030130 | pubmed:author | pubmed-author:MayrhoferGrah... | lld:pubmed |
| pubmed-article:16030130 | pubmed:author | pubmed-author:MoghaddamiMah... | lld:pubmed |
| pubmed-article:16030130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16030130 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:16030130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16030130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16030130 | pubmed:pagination | 1103-15 | lld:pubmed |
| pubmed-article:16030130 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:meshHeading | pubmed-meshheading:16030130... | lld:pubmed |
| pubmed-article:16030130 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16030130 | pubmed:articleTitle | MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro. | lld:pubmed |
| pubmed-article:16030130 | pubmed:affiliation | Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia. | lld:pubmed |
| pubmed-article:16030130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16030130 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16030130 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16030130 | lld:pubmed |
