Source:http://linkedlifedata.com/resource/pubmed/id/16005121
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
42
|
| pubmed:dateCreated |
2005-9-13
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| pubmed:abstractText |
VEE replicon particles (VRP), non-propagating vaccine vectors derived from Venezuelan equine encephalitis virus (VEE), were engineered to express immunogens from the cloned isolate SIVsmH-4, combined in a vaccine cocktail and inoculated subcutaneously to immunize rhesus macaques. The virulent, uncloned challenge stock, SIVsmE660, represented a type of heterologous challenge and the intrarectal challenge modeled infection across a mucosal surface. Prechallenge neutralizing antibodies against SIVsmH-4 were induced in all vaccinates, and a prechallenge cellular immune response could be detected in one of six. Post-challenge, virus loads were reduced at the peak, at set point and at termination (41 weeks post-challenge), although these differences did not reach statistical significance. Significantly elevated levels of CD4+ T cells were observed post-challenge. A strong correlation was noted between a net increase in CD4+ T cell count and lowered virus load at set point.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0264-410X
|
| pubmed:author |
pubmed-author:CecilChadC,
pubmed-author:CollierMartha LML,
pubmed-author:ConnellMary JMJ,
pubmed-author:DavisNancy LNL,
pubmed-author:FrelingerJeffrey AJA,
pubmed-author:JohnsonPhilip RPR,
pubmed-author:JohnstonRobert ERE,
pubmed-author:MontefioriDavid CDC,
pubmed-author:SwanstromRonaldR,
pubmed-author:WestAndeA
|
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4969-79
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:16005121-Animals,
pubmed-meshheading:16005121-Antibodies, Viral,
pubmed-meshheading:16005121-CD4 Lymphocyte Count,
pubmed-meshheading:16005121-Disease Models, Animal,
pubmed-meshheading:16005121-Encephalitis Virus, Venezuelan Equine,
pubmed-meshheading:16005121-Genetic Vectors,
pubmed-meshheading:16005121-Immunity, Cellular,
pubmed-meshheading:16005121-Injections, Subcutaneous,
pubmed-meshheading:16005121-Macaca mulatta,
pubmed-meshheading:16005121-Neutralization Tests,
pubmed-meshheading:16005121-Replicon,
pubmed-meshheading:16005121-SAIDS Vaccines,
pubmed-meshheading:16005121-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:16005121-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:16005121-Vaccines, Synthetic,
pubmed-meshheading:16005121-Viral Load,
pubmed-meshheading:16005121-Viral Vaccines
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Vaccination of macaques with SIV immunogens delivered by Venezuelan equine encephalitis virus replicon particle vectors followed by a mucosal challenge with SIVsmE660.
|
| pubmed:affiliation |
Carolina Vaccine Institute, School of Medicine, University of North Carolina, CB#7292, Chapel Hill, NC 27599, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|