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rdf:type |
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lifeskim:mentions |
umls-concept:C0007099,
umls-concept:C0017262,
umls-concept:C0038250,
umls-concept:C0086418,
umls-concept:C0205851,
umls-concept:C0231044,
umls-concept:C0521457,
umls-concept:C0677483,
umls-concept:C1171362,
umls-concept:C1427164,
umls-concept:C1515670,
umls-concept:C1521761
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pubmed:issue |
1
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pubmed:dateCreated |
2005-6-28
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pubmed:abstractText |
NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/NANOG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/POU5F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/alkaline phosphatase, placental
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0309-0167
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-56
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15982323-Adolescent,
pubmed-meshheading:15982323-Adult,
pubmed-meshheading:15982323-Alkaline Phosphatase,
pubmed-meshheading:15982323-Carcinoma in Situ,
pubmed-meshheading:15982323-Cell Transformation, Neoplastic,
pubmed-meshheading:15982323-Child,
pubmed-meshheading:15982323-Child, Preschool,
pubmed-meshheading:15982323-DNA-Binding Proteins,
pubmed-meshheading:15982323-Fetus,
pubmed-meshheading:15982323-GPI-Linked Proteins,
pubmed-meshheading:15982323-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15982323-Germinoma,
pubmed-meshheading:15982323-Gestational Age,
pubmed-meshheading:15982323-Homeodomain Proteins,
pubmed-meshheading:15982323-Humans,
pubmed-meshheading:15982323-Immunohistochemistry,
pubmed-meshheading:15982323-In Situ Hybridization,
pubmed-meshheading:15982323-Isoenzymes,
pubmed-meshheading:15982323-Male,
pubmed-meshheading:15982323-Octamer Transcription Factor-3,
pubmed-meshheading:15982323-RNA, Messenger,
pubmed-meshheading:15982323-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15982323-Testicular Neoplasms,
pubmed-meshheading:15982323-Transcription Factor AP-2,
pubmed-meshheading:15982323-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours.
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pubmed:affiliation |
University Department of Growth & Reproduction and Department of Pathology, Rigshospitalet, Copenhagen, Denmark. chh@dadlnet.dk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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