| pubmed-article:15979578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0521339 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0376196 | lld:lifeskim |
| pubmed-article:15979578 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15979578 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15979578 | pubmed:dateCreated | 2005-7-4 | lld:pubmed |
| pubmed-article:15979578 | pubmed:abstractText | In order to investigate if beta-endorphins anti-inflammatory effect in cartilage-damaging states is mediated via tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), we examined its influence on these two cytokines in vitro. Human articular chondrocytes were obtained from patients undergoing total knee arthroplasty and stimulated with beta-endorphin (60-6000 ng/ml). Protein levels of TNF-alpha and IL-1 beta were measured by ELISA in supernatants from articular chondrocyte cultures. beta-Endorphin significantly increased the levels of IL-1 beta for all concentrations used after 15 min incubation, and when stimulated with 600 and 6000 ng/ml after 24 h incubation. The opioid-induced increase in IL-1 beta was blocked by naltrexone in the group tested. TNF-alpha expression was also significantly stimulated by 60 and 600 ng/ml beta-endorphin after 15 min, an effect blocked by naltrexone in the group tested. These findings indicate that the mechanism of beta-endorphins anti-inflammatory influence in cartilage-damaging states is not apparently mediated via these two cytokines modulation. | lld:pubmed |
| pubmed-article:15979578 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15979578 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15979578 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15979578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15979578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15979578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15979578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15979578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15979578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15979578 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15979578 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15979578 | pubmed:author | pubmed-author:MartinJamesJ | lld:pubmed |
| pubmed-article:15979578 | pubmed:author | pubmed-author:JohansenOddmu... | lld:pubmed |
| pubmed-article:15979578 | pubmed:author | pubmed-author:ElvenesJanJ | lld:pubmed |
| pubmed-article:15979578 | pubmed:author | pubmed-author:AndjelkovNena... | lld:pubmed |
| pubmed-article:15979578 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15979578 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15979578 | pubmed:volume | 333 | lld:pubmed |
| pubmed-article:15979578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15979578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15979578 | pubmed:pagination | 1295-9 | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
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| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:meshHeading | pubmed-meshheading:15979578... | lld:pubmed |
| pubmed-article:15979578 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15979578 | pubmed:articleTitle | Opiate regulation of IL-1beta and TNF-alpha in cultured human articular chondrocytes. | lld:pubmed |
| pubmed-article:15979578 | pubmed:affiliation | Department of Orthopaedics, University Hospital of Northern-Norway, 9038 Tromsø, Norway. nenad.andjelkov@fagmed.uit.no | lld:pubmed |
| pubmed-article:15979578 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15979578 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15979578 | lld:pubmed |
