Linked Life Data

15970506

Source:http://linkedlifedata.com/resource/pubmed/id/15970506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-6-22
pubmed:abstractText
The population explosion and unintended pregnancies resulting in elective abortions continue to be the major public health issues in spite of availability of current methods of contraception. There is an urgent need for a better method of contraception that is accepted, effective, and available. Various targets are being investigated that can be used for contraception. The gene knockout technology is a powerful approach to identify such novel targets. Using search in the database, at least 93 genes were identified in the literature whose deletion demonstrated an effect on fertility in male mice. However, majority of these knockouts also demonstrated an effect on non-reproductive organs concomitant with an effect on fertility. The knockouts of only a few genes/proteins induced a specific effect on fertility without a serious side effect. The potential role of these novel genes/proteins in contraception/contraceptive vaccine development is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2430-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Novel testis/sperm-specific contraceptive targets identified using gene knockout studies.
pubmed:affiliation
Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Science Center, Morgantown, WV 28506-9186, USA. rnaz@hsc.wvu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, N.I.H., Extramural