Linked Life Data

15956284

Source:http://linkedlifedata.com/resource/pubmed/id/15956284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-9-20
pubmed:abstractText
Most patients with de novo chronic myeloid leukemia (CML) achieve good responses to imatinib, but the rate and degree of molecular response is variable. We assessed the inhibitory concentration 50% for imatinib (IC50imatinib) in 62 patients with de novo chronic-phase CML as a predictor of molecular response. IC50imatinib was determined in pretherapy blood samples by measuring the in vitro imatinib-induced reduction of the phosphorylated form of the adaptor protein Crkl (CT10 regulator of kinase like). There was marked variability between patients, with IC50imatinib ranging from 0.375 to 1.8 microM (median, 0.6 microM). Patients with low IC50imatinib (IC50 < or = 0.6 microM; n = 36) had a 36% probability of achieving 2-log reduction in BCR-ABL (breakpoint cluster region-abelson) by 3 months compared with 8% in patients with high IC50imatinib (n = 26) (P = .01). The IC50imatinib was also predictive of molecular response at 12 months, with 47% of patients in the low IC50imatinib group achieving 3-log reduction and 23% in the high IC50imatinib group (P = .03). The predictive power of IC50imatinib was particularly strong in patients with low Sokal scores. These data provide strong evidence that intrinsic sensitivity to imatinib is variable in previously untreated patients with CML, and the actual level of BCR-ABL kinase inhibition achieved is critical to imatinib response. The IC50imatinib potentially provides a new prognostic indicator for molecular response in patients treated with imatinib.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2520-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15956284-Adaptor Proteins, Signal Transducing, pubmed-meshheading:15956284-Antineoplastic Agents, pubmed-meshheading:15956284-Blotting, Western, pubmed-meshheading:15956284-Cell Proliferation, pubmed-meshheading:15956284-Chromosomes, Human, Pair 9, pubmed-meshheading:15956284-Dose-Response Relationship, Drug, pubmed-meshheading:15956284-Drug Screening Assays, Antitumor, pubmed-meshheading:15956284-Fusion Proteins, bcr-abl, pubmed-meshheading:15956284-Genes, abl, pubmed-meshheading:15956284-Humans, pubmed-meshheading:15956284-Inhibitory Concentration 50, pubmed-meshheading:15956284-K562 Cells, pubmed-meshheading:15956284-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:15956284-Nuclear Proteins, pubmed-meshheading:15956284-Oncogene Proteins, pubmed-meshheading:15956284-Phosphorylation, pubmed-meshheading:15956284-Piperazines, pubmed-meshheading:15956284-Prognosis, pubmed-meshheading:15956284-Protein Kinase Inhibitors, pubmed-meshheading:15956284-Proto-Oncogene Proteins c-abl, pubmed-meshheading:15956284-Pyrimidines, pubmed-meshheading:15956284-Time Factors, pubmed-meshheading:15956284-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML.
pubmed:affiliation
Division of Haematology, Institute of Medical and Veterinary Science (IMVS) and Hanson Institute, Adelaide, Australia. deb.white@imvs.sa.gov.au
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't