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pubmed-article:15956160pubmed:abstractTextThere is an increasing body of evidence that magnetic resonance imaging-occult tissue damage is an important component of primary progressive multiple sclerosis (PPMS) pathology. Proton magnetic resonance spectroscopy (1H-MRS) can be used to measure in vivo whole-brain N-acetylaspartate (WBNAA) concentrations, the decrease of whose levels is considered a marker of neuronal-axonal injury.lld:pubmed
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pubmed-article:15956160pubmed:articleTitleAxonal injury and overall tissue loss are not related in primary progressive multiple sclerosis.lld:pubmed
pubmed-article:15956160pubmed:affiliationNeuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.lld:pubmed
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