|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2005-8-1
|
|
pubmed:abstractText |
This study was performed to investigate whether or not amiloride, a sodium-hydrogen exchanger (NHE) inhibitor, can protect against seizure development of pentylenetetrazole (PTZ)-induced kindling in mice.Kindling was induced by once every 2 days treatment with PTZ (25 mg kg(-1) i.p.) for 5 weeks. Challenge experiments were carried out after 15 or 30 days of last treatment with PTZ. Administration of amiloride (2 h before PTZ, in doses of 0.65 and 1.3 mg kg(-1), p.o.) significantly prolonged the onset of kindling and reduced the incidence and severity of seizures in a dose-dependent manner. The effect of amiloride on the incidence of PTZ-induced seizures was evident even after 15 or 30 days of last treatment. The results indicate a protective role for amiloride against PTZ-induced kindling in mice. The possibility of mediation of such effects by NHE inhibition is discussed.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-10336561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-10662818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-10963758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-11564118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-1279865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-15145301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-1967968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-2192394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-2469590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-2894627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-2973979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-3009822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-3396627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-4563784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-7012859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-7913139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-8094739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-8381871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-8422858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-9016300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-9200742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-9335342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-9655239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15951829-9853109
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
145
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
880-4
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:15951829-Amiloride,
pubmed-meshheading:15951829-Animals,
pubmed-meshheading:15951829-Anticonvulsants,
pubmed-meshheading:15951829-Convulsants,
pubmed-meshheading:15951829-Diazepam,
pubmed-meshheading:15951829-Dose-Response Relationship, Drug,
pubmed-meshheading:15951829-Kindling, Neurologic,
pubmed-meshheading:15951829-Male,
pubmed-meshheading:15951829-Mice,
pubmed-meshheading:15951829-Pentylenetetrazole,
pubmed-meshheading:15951829-Seizures
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Amiloride protects against pentylenetetrazole-induced kindling in mice.
|
|
pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi 110062, India.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
