Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2005-6-8
pubmed:abstractText
Invasion by colorectal carcinomas is characterized by an epithelial-mesenchymal transition (EMT)-like dedifferentiation of the tumor cells. However, a redifferentiation towards an epithelial phenotype, resembling a mesenchymal-epithelial transition, is detectable in metastases. This indicates that malignant progression is based on dynamic processes, which cannot be explained solely by irreversible genetic alterations, but must be additionally regulated by the tumor environment. The main oncoprotein in colorectal cancer is the Wnt pathway effector beta-catenin, which is overexpressed due to mutations in the APC tumor suppressor in most cases. EMT of the tumor cells is associated with a nuclear accumulation of the transcriptional activator beta-catenin, which is reversed in metastases. Nuclear beta-catenin is involved in two fundamental processes in embryonic development: EMT and stem cell formation. Accumulating data demonstrate that aberrant nuclear expression of beta-catenin can also confer these two abilities to tumor cells, thereby driving malignant tumor progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1422-6405
pubmed:author
pubmed:issnType
Print
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-65
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:15942193-Cell Nucleus, pubmed-meshheading:15942193-Colorectal Neoplasms, pubmed-meshheading:15942193-Cytoskeletal Proteins, pubmed-meshheading:15942193-Disease Progression, pubmed-meshheading:15942193-Embryonic Development, pubmed-meshheading:15942193-Epithelial Cells, pubmed-meshheading:15942193-Epithelium, pubmed-meshheading:15942193-Genes, APC, pubmed-meshheading:15942193-Humans, pubmed-meshheading:15942193-Immunohistochemistry, pubmed-meshheading:15942193-Mesoderm, pubmed-meshheading:15942193-Models, Biological, pubmed-meshheading:15942193-Neoplasm Invasiveness, pubmed-meshheading:15942193-Neoplasm Metastasis, pubmed-meshheading:15942193-Signal Transduction, pubmed-meshheading:15942193-Stem Cells, pubmed-meshheading:15942193-Trans-Activators, pubmed-meshheading:15942193-beta Catenin
pubmed:year
2005
pubmed:articleTitle
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin.
pubmed:affiliation
Department of Pathology, University of Erlangen-Nurnberg, Erlangen, Germany. thomas.brabletz@patho.imed.uni-erlangen.de
pubmed:publicationType
Journal Article, Review